哺乳动物雷帕霉素靶蛋白信号通路与眼科疾病相关性的研究进展  

Advance in research on the relationship between mammalian target of rapamycin signaling pathway and ophthalmic diseases

作　　者：张桂铭[1] 刘红玲[1] 傅少颖[1] 

机构地区：[1]哈尔滨医科大学附属第一医院眼科,150000

出　　处：《中华实验眼科杂志》2015年第11期1048-1051,共4页Chinese Journal Of Experimental Ophthalmology

基　　金：国家自然科学基金项目（30970749、81301325）

摘　　要：哺乳动物雷帕霉素靶蛋白（mTOR）是一种高度进化保守的蛋白激酶，控制细胞生长、生长因子和细胞能量的形成，参与营养、新陈代谢及老化过程，近年发现mTOR信号通路与细胞生长、调控蛋白质合成代谢密切相关，已成为肿瘤形成、代谢紊乱、神经系统疾病和炎症等疾病的重要通路。就mTOR及通路介导的眼科疾病进行综述。Mammalian target of rapamycin （roTOR） is a highly evolutionary conserved protein kinase and plays a critical role in the regulation of cell growth, growth factors and cell energy, and thus contributes to the formation of nutrition, metabolism and aging processes. Recent studies found that mTOR signaling pathway is associated with cell cycle, protein synthesis and metabolism, and it is an important pathway of diseases such as development of tumor,metabolic disorders,nervous system disease and inflammation. The relationship between roTOR signaling pathway and ophthalmic diseases was reviewed in this article.

关 键 词：哺乳动物雷帕霉素靶蛋白 信号通路 雷帕霉素 眼科疾病 

分 类 号：R77[医药卫生—眼科]