荧光诊断在皮肤肿瘤中的应用进展  

Application of fluorescence diagnosis in skin tumors

作　　者：罗毅鑫[1] 刘洁[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730

出　　处：《国际皮肤性病学杂志》2015年第6期396-398,共3页International Journal of Dermatology and Venereology

摘　　要：荧光诊断具有非侵入、操作简便、实时检测等优点，临床上已用于检测多种早期浅表肿瘤。在皮肤肿瘤中，荧光诊断可用于非色素性皮肤肿瘤的辅助诊断、Mohs手术前皮损范围的确定、疗效评价及治疗后的随访。荧光诊断中荧光强度和诊断准确性受到光敏剂，激发光强度，皮损类型、大小及位置，皮损周围皮肤状态等多种因素的影响。荧光诊断在皮肤肿瘤临床应用中的效果，不同研究的结果并不完全一致，尚需要大量的病例对照研究进行证实。Fluorescence diagnosis is a convenient, non-invasive and real-time diagnostic tool which has been applied to detect early-stage superficial tumors. As far as skin tumors are concerned, it can be used for the auxiliary diagnosis of nonpigmented skin tumors, delineation of lesions before Mobs micrographic surgery （MMS）, efficacy evaluation and posttreatment follow up. The intensity of fluorescence and accuracy of fluorescence diagnosis are influenced by the type of photosensitizers, intensity of excitation light, type, size and location of lesions, status of perilesional skin, and so on. There have been multiple studies on the efficiency of fluorescence diagnosis in skin tumors, but the results are controversial, and large-scale case-control studies are required to further evaluate it.

关 键 词：皮肤肿瘤 光谱法 荧光 诊断 光敏感药 影响因素分析 

分 类 号：R739.5[医药卫生—肿瘤]