BMI-1蛋白在慢性粒细胞白血病中的表达及意义  

Expression of BMI-1 protein in CML Cells and its Clinical Significance

作　　者：葛熙[1] 洪煜婧 赵枰[1] 

机构地区：[1]南通大学第二附属医院检验科,江苏南通226001 [2]南通大学公共卫生学院,预防医学141班江苏南通226019

出　　处：《实验与检验医学》2015年第5期598-599,611,共3页Experimental and Laboratory Medicine

基　　金：江苏省南通市科技计划项目(2014年度HS149058)

摘　　要：目的探讨BMI-1蛋白在慢性粒细胞白血病各期中的表达及意义。方法采用免疫化学SP法测定BMI-1蛋白在对照组及CML各期中的表达。结果 BMI-1蛋白在CML-AP/BP组的表达显著高于对照组和CML-CP组(P<0.05),CMLCP组和对照组比较差异无统计学意义(P>0.05);BMI-1蛋白在CML-AP/BP未缓解组明显高于缓解组(P<0.05)。结论 BMI-1蛋白在CML-AP/BP骨髓单个核细胞中高表达且与CML发生急变及预后相关。Objective To investigate the expression and significance of BMI-1 protein in control group and in different phases of CML. Method The immunohistochemical SP staining was used to detect expression of BMI-1 protein in control group and in different phases of CML. Result Expression of BMI-1 protein in CML-AP/BP group was significantly higher than that in control group and that in CML-CP group（P〈0.05）,expression of BMI-1 protein in control group and CML-CP group had no significant difference（P〉0.05）. Expression of BMI-1 protein in no remission group was significantly higher than that in complete remission group（P〈0.05）. Conclusion The high expression of BMI-1 protein in CML bone marrow mononuclear cells plays an important role in CML blast crisis and prognosis

关 键 词：白血病 BMI1 免疫组化 

分 类 号：R733.7[医药卫生—肿瘤] R446.62[医药卫生—临床医学]