三维适形放疗联合小剂量多西他赛+顺铂治疗晚期食管癌患者近期疗效和安全性  被引量:9

The concurrent efficacy of low dose TP term radiotherapy and chemotherapy for esophageal cancer

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作  者:范瑞华[1] 张铁成[1] 姚榕[1] 黄明德[1] 

机构地区:[1]南京医科大学附属淮安第一医院肿瘤内科,223300

出  处:《疑难病杂志》2015年第11期1118-1121,共4页Chinese Journal of Difficult and Complicated Cases

摘  要:目的观察三维适形放疗联合小剂量TP(多西他赛+顺铂)化疗对食管癌患者的近期疗效和安全性。方法晚期食管癌患者56例随机分为观察组和对照组各28例。观察组予以三维适形放疗联合小剂量TP化疗,对照组予以三维适形放疗。对比2组患者治疗前后临床症状积分、近期疗效、不良反应发生率和生活质量评分(卡氏评分)。结果 2组患者治疗后的声音嘶哑、进食梗阻和饮水呛咳积分均显著低于治疗前(P<0.05),且观察组声音显著低于对照组(P<0.05)。观察组近期缓解率为89.28%,高于对照组的42.86%(P<0.05)。观察组患者的放射性食管炎、恶心呕吐和骨髓抑制总发生率分别为60.72%、25.00%和64.29%,对照组患者分别为53.57%、28.57%和60.71%,2组比较差异无统计学意义(P<0.05)。2组患者治疗后的卡氏评分显著高于治疗前[观察组为(75.64±2.36)分vs.(82.09±3.39)分,对照组为(74.60±2.63)分vs.(78.27±3.01)分,P<0.05],且治疗后观察组的卡氏评分显著高于对照组(P<0.05)。结论小剂量多西他赛与顺铂化疗联合三维适形放疗治疗食管癌患者是安全、有效的。Objective To observe the short term efficacy and safety of three-dimensional confornial radiotherapy combined with small dose of TP(docetaxel + cisplatin) chemotherapy for patients with esophageal cancer.Methods 56 cases of esophageal cancer patients were randomly divided into observation group and control group with 28 cases in each group.Three dimensional confornial radiotherapy combined with low-dose TP chemotherapy were performed in the observation group,and the control group was treated with three-dimensional conlormal radiotherapy.The clinical symptom score,the short-term efficacy,the incidence of adverse reactions and the quality of life score were compared between the 2 groups before and after treatment.Results After treatment,the patients in both of the two groups' hoarseness,eating obstruction and drinking cough score were significantly lower than those before treatment(P〈0.05),and the observation group's hoarseness was significantly lower than that of control group(P〈0.05).The observation group's short term improvement rate was 89.28%,which was higher than 42.86%in the control group(P0.05).Observation group patients' radiation-induced esophageal inflammation,nausea and vomiting,bone marrow inhibited total incidence rate were 60.72%and 25.00%and 64.29%respectively,the control group patients were 53.57%,28.57%,60.71%respectively,the difference between the 2 groups did not show statistically significant(P〈0.05).Karnofsky score of the two groups after treatment was significantly higher than that of before treatment(75.64 ±2.36) points vs.(82.09±3.39) points,(74.60±2.63) points vs.(78.27 ± 3.01)points,respectively,P〈0.05) and after treatment observation group's Karnofsky score was significantly higher than that of the control group(P〈0.05).Conclusion Low dose of docetaxel and cisplatin chemotherapy combined with three-dimensional confornial radiotherapy for patients with esophageal cancer is safe and effective.

关 键 词:食管癌 适形放疗 同步放化疗 

分 类 号:R735.1[医药卫生—肿瘤]

 

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