microRNA-155在肾透明细胞癌中的表达及意义  

The expression and value of miR-155 in clear renal cell carcinoma

作　　者：张冰[1] 纪洪[2] 燕东亮[1] 吴淑华[2] 

机构地区：[1]滨州医学院附属医院泌尿外科,滨州256603 [2]滨州医学院附属医院病理科

出　　处：《滨州医学院学报》2015年第5期340-342,共3页Journal of Binzhou Medical University

摘　　要：目的探讨miR-155在肾透明细胞癌（clear renal cell carcinoma,CCRCC）中的表达及意义。方法采用实时定量PCR技术检测18例CCRCC患者新鲜肿瘤组织及癌旁非肿瘤组织中miR-155的表达情况。结果与配对的癌旁非肿瘤组织相比,肿瘤组织中miR-155的表达在16例（88.9%）的样本中上调,在2例样本中表达下调,其中CCRCC中miR-155的相对表达量为2.08~26.05,平均（12.70±6.52）,癌旁非肿瘤组织中相对表达量为1.00~6.79,平均为（2.82±1.25）,改变有显著统计学差异（P〈0.05）。根据病理分级样分组,高分化组miR-155的相对含量为（11.43±6.18）,中-低分化组为（14.33±7.04）,结果有显著统计学差异（P〈0.05）。结论 miR-155表达上调可能与CCRCC的发病机制相关,其表达水平与Fuhrman病理分级密切相关。Objective To explore the functional role and mechanism of miR-155 in the development of clear cell renal cell carcinoma（CCRCC）.Methods MiR-155 expression was quantified in renal cancers and matched adjacent non tumor tissues using quantitative real-time PCR（RT-PCR）.Results MiR-155 expressions were up-regulated in 16 renal cancer tissues（88.9%）and down-regulated in 2renal cancer tissues.Expression level of miR-155 in renal cancer tissues was significantly higher than that in adjacent normal tissues（12.70±6.52 vs 2.82±1.25,P0.05）and higher expression of miR-155 was observed in cases with higher stages（11.43±6.18 vs 14.33±7.04,P0.05）.Conclusion Upregulation of miR-155 may be associated with the pathogenesis of CCRCC,and the expression level is closely related with the Fuhrman pathological grading.

关 键 词：microRNA-155 肾细胞癌 分级 

分 类 号：R737.11[医药卫生—肿瘤]