持续输注右美托咪啶对肺癌根治术患者肺功能及苏醒质量的影响  

Effect of continuous infusion dexmedetomidine on patients with lung cancer radical resection

作　　者：王渊[1] 石源[1] 尹卓伟[1] 温来友[2] 吴震[2] 

机构地区：[1]东南大学医学院附属江阴医院ICU,江苏江阴214400 [2]东南大学医学院附属江阴医院麻醉科,江苏江阴214400

出　　处：《中华肺部疾病杂志（电子版）》2015年第5期56-59,共4页Chinese Journal of Lung Diseases(Electronic Edition)

摘　　要：目的探讨持续输注右美托咪啶对肺癌根治术患者肺功能及苏醒质量的影响。方法选择东南大学医学院附属江阴医院2014年1月至2015年1月住院60例肺癌根治患者,60例术毕送ICU继续呼吸机支持治疗,随机分为观察组30例和对照组30例。对照组诱导前10 min输注丙泊酚2 mg·kg-1·h-1,术毕继续输注至患者入ICU 30 min,观察组诱导前10 min输注右美托咪啶1μg·kg-1·h-1,后改为0.5μg·kg-1·h-1至患者入ICU 30 min。比较两组苏醒质量和肺功能变化。结果拔管时观察组平均动脉压、心率显著低于对照组(P<0.05);两组苏醒时间比较差异无统计学意义(P>0.05),观察组躁动评分显著低于对照组(P<0.05)。观察组肺内分流率明显低于对照组(P<0.05),而氧合指数和动脉血氧分压/肺泡氧分压显著高于对照组(P<0.05)。结论持续输注右美托咪啶可明显改善肺癌根治术患者苏醒质量,改善术后肺功能。Objective To investigate the effect of continuous infusion of dexmedetomidine on patients with lung cancer radical resection. Methods 60 cases of lung cancer patients with radical surgery,which were sended to ICU for ventilator support therapy after operation,were randomly divided into the observation group（ 30cases） and the control group（ 30cases）. Continuous infusion of propofol 2 mg·kg- 1·h- 1was given in10 min before induction and in 30 min in ICU after operation in the control group,continuous infusion of dexmedetomidine1 μg · kg- 1· h- 1was given in 10 min before induction, and continuous infusion of dexmedetomidine 0. 5 μg · kg- 1·h- 1was done in 30 min in ICU after operation in the observation group.Awakening quality and lung function were compared in two groups. Results During extubation,mean arterial pressure,heart rate in the observation group were significantly lower than those in the control group（ P 〈0. 05）. There was not statistically significant difference in the recovery time in two groups（ P 〉 0. 05）,Agitation scores in the observation group were significantly lower than those in the control group（ P 〈 0. 05）.s / t in the observation group was significantly lower than that in the control group（ P 〈 0. 05）,while the oxygenation index and arterial oxygen tension / alveolar oxygen partial pressure were significantly higher than those the control group（ P 〈 0. 05）. Conclusions Continuous infusion of dexmedetomidine significantly improved the awakening quality and postoperative lung function in patients with lung cancer radical resection.

关 键 词：肺癌根治术 苏醒质量 肺功能 右美托咪啶 

分 类 号：R734.2[医药卫生—肿瘤]