长链非编码RNAs在乳腺癌中的表达及其功能  

The expression and functions of long non-coding RNAs in breast cancer

作　　者：陈双双[1,2] 于正洪[1,2] 

机构地区：[1]南京中医药大学第一临床医学院 [2]南京军区南京总医院肿瘤内科,南京210002

出　　处：《临床肿瘤学杂志》2015年第10期943-947,共5页Chinese Clinical Oncology

基　　金：国家自然科学基金项目(81272260);江苏省六大人才高峰基金项目(BK2009284)

摘　　要：无蛋白编码功能的非编码RNAs(ncRNAs)具有多种生物学功能。长链非编码RNAs(LncRNAs)是近年来发现的ncRNAs的一员,其转录长度200 nt^100 kb。许多长链非编码RNAs异常表达具有促进或抑制肿瘤发生、发展的生物学功能,包括乳腺癌。由于其在调控基因表达中的基础性作用,和其参与潜在的肿瘤发生的生物学机制,它们是一类有前途的癌症生物标志物。本文突出LncRNAs在乳腺癌中的新兴作用,并探讨其在乳腺癌的诊断、治疗和预后等相关潜在的临床应用价值。The non coding RNAs（ ncRNAs） with no protein coding function have a variety of biological functions. The long non coding RNAs（ LncRNAs） are a member of ncRNAs found in recent years. The transcript length of LncRNAs range from 200 nt to100 kb. The abnormal expression of many lncRNAs has the biological functions of facilitating or inhibiting the development and progression of tumor,including breast cancer. Because of their fundamental roles in regulating gene expression and their potential roles in tumor genesis,they are promising class of tissue-and / or blood-based cancer biomarkers. In this review,we will highlight the emerging roles of lncRNAs in breast cancer,and explore their potential clinical value in diagnosis,treatment and prognosis of breast cancer.

关 键 词：长链非编码RNAs 乳腺癌 生物标志物 治疗靶点 

分 类 号：R737.9[医药卫生—肿瘤]