游离棉酚代谢产物gossypolone的半合成法制备及质谱表征  

Semi-synthesis of gossypolone from free gossypol and the structure was identified by mass spectra

作　　者：姚军[1,2] 武钰[2] 张煌涛 李东雨[2] 鹿毅 李莉[2] 

机构地区：[1]新疆产品质量监督检验研究院,新疆乌鲁木齐830004 [2]新疆医科大学药学院,新疆乌鲁木齐830054

出　　处：《应用化工》2015年第10期1960-1962,共3页Applied Chemical Industry

基　　金：国家自然科学基金项目(31160322;31460417)

摘　　要：以棉酚为原料,采用半合成方法,制备棉酚氧化产物gossypolone,采用ESI-QTOF/MS飞行时间质谱和LCMS/MS对产物的结构进行验证,用HPLC分析产物的纯度。结果显示,产物的分子量、分子式、结构式均与棉酚氧化产物gossypolone一致,可以推测产物为棉酚氧化产物gossypolone,纯度≥95%。The oxidization process of gossypol was simulated by Semi-synthesis to prepare the gossypolone. Then the structure of oxidization product was identified by LC-MS / MS and ESI-QTOF / MS,the purity was analyzed by HPLC. The results indicated that the molecular weight,molecular formula,structural formula of product prepared in experiment were consistent with gossypolone. It can be inferred that the oxidization product was gossypolone,and the product content was up to 95%.

关 键 词：棉酚 代谢产物 gossypolone 质谱 纯度 

分 类 号：TQ07[化学工程] TQ24