肝衰竭患者MARS人工肝治疗前后不同疗效组外周血TNF-α mRNA和IL-6 mRNA的表达  

mRNA Expression of TNF-α and IL- 6 in the Peripheral Blood from Liver Failure Patients before and after MARS Treatment

作　　者：阿永俊[1] 刘锋[1] 李春满[1] 陈鹏[1] 邹智荣[2] 

机构地区：[1]昆明医科大学第二附属医院肝胆外科,云南昆明650101 [2]昆明医科大学人体解剖学与组织胚胎学系,云南昆明650500

出　　处：《昆明医科大学学报》2015年第10期90-93,共4页Journal of Kunming Medical University

基　　金：云南省教育厅科学研究基金资助项目(2014Z065)

摘　　要：目的研究肝衰竭患者MARS人工肝治疗前后好转组和恶化组外周血TNF-αm RNA和IL-6m RNA的表达.方法对33例肝衰竭患者进行MARS人工肝治疗,采用RT-PCR检测外周血好转组和恶化组TNF-αm RNA和IL-6 m RNA的表达.结果好转组和恶化组所有患者在MARS人工肝治疗前外周血TNF-αm RNA和IL-6 m RNA均为强阳性表达,治疗后好转组TNF-αm RNA和IL-6 m RNA强阳性表达率较恶化组降低,2组比较差异有统计学意义(P<0.01).结论外周血TNF-αm RNA和IL-6 m RNA有可能作为肝衰竭患者接受MARS人工肝治疗后判断预后的指标.Objective To study the m RNA expression of TNF- αand IL- 6 in the peripheral blood from liver failure patients before and after MARS treatment in the improving and worsening groups. Methods Thirty- three patients with liver failure were treated with MARS treatment,and the expression of TNF- αm RNA and IL- 6 m RNA in the peripheral blood of patients were detected using RT- PCR method. Results Strong positive expression could be observed in all liver failure patients before MARS treatment, while the strong positive expression rates of TNF- αm RNA and IL- 6 m RNA of patients in improving group were lower than those in worsening group after MARS treatment. Conclusion TNF- αm RNA and IL- 6 m RNA in the peripheral blood can be taken as an indicator for the prognosis of liver failure patients.

关 键 词：肝衰竭 分子吸附再循环系统 肿瘤坏死因子-α 白介素-6 

分 类 号：R575.3[医药卫生—消化系统]