逍遥散中抗抑郁有效成分及其作用机制研究进展  

Research progress on antidepressive active ingredients of Xiaoyaosan and their mechanism

作　　者：李肖[1,2] 宫文霞[1,2] 周玉枝[1] 高丽[1] 高晓霞[1] 田俊生[1] 秦雪梅[1] 杜冠华[3] 

机构地区：[1]山西大学中医药现代研究中心,山西太原030006 [2]山西大学化学化工学院,山西太原030006 [3]中国医学科学院药物研究所,北京100050

出　　处：《中草药》2015年第20期3109-3116,共8页Chinese Traditional and Herbal Drugs

基　　金：国家国际科技合作项目(2011DFA32630);"重大新药创制"科技重大专项(2012ZX09103201-035);山西省科技攻关项目(20140313008-14);山西省科技基础条件平台建设项目(2014091022)

摘　　要：逍遥散具有明确的抗抑郁作用,但是其抗抑郁有效成分及其作用机制尚不清楚。从作用到成分、成分到机制2条途径,归纳总结了逍遥散中的抗抑郁有效成分以及这些成分发挥抗抑郁作用的可能机制,进一步确证了逍遥散作为经典抗抑郁古方所具有的多层次、多途径、多靶点等特点。The antidepressive effect of Xiaoyaosan is obvious, however, the active ingredients with potential antidepressive activity and their mechanism remain unclear. In this paper, by two ways of the effects to active ingredients and the active ingredients to mechanism, the antidepressive active ingredients and their mechanism of Xiaoyaosan are summarized. Xiaoyaosan as a classic antidepressant Chinese prescription is further confirmed with many advantages, such as multi-level, multi-channel, multi-target, and so on.

关 键 词：逍遥散 抗抑郁 槲皮素 甘草苷 柴胡皂苷 芍药苷 阿魏酸 姜黄素 

分 类 号：R285[医药卫生—中药学]