非酒精性脂肪性肝病患者血清VEGF水平与IL-6、hs-CRP的相关性分析  

Correlation between Vascular Endothelial Growth Factor and Interleukin-6,High-sensitivity C-reactive Protein in Patients with Nonalcoholic Fatty Liver Disease

作　　者：欧阳小予[1] 陈建平[1] 杨阳[1] 刘桑燕[1] 

机构地区：[1]三明市第二医院消化内科,福建省永安市366000

出　　处：《医学理论与实践》2015年第19期2589-2590,2609,共3页The Journal of Medical Theory and Practice

摘　　要：目的:探讨非酒精性脂肪性肝病(NAFLD)患者血清血管内皮生长因子(VEGF)与白介素-6(IL-6)、高敏C反应蛋白(hs-CRP)、白细胞计数(WBC)的相关性。方法:选取2013年1月-2015年1月在我院明确诊断NAFLD患者122例,同时选取同期门诊健康体检者108例作为研究对象,采用全自动生化检测仪检测相关生化指标,通过酶联免疫吸附试验(ELISA)检测血清中VEGF、IL-6水平,免疫比浊法检测血清hs-CRP水平。结果:与对照组比较,脂肪肝组在臀围、腰围、体质指数、收缩压、舒张压、丙氨酸氨基转氨酶、天门冬氨酸转氨酶、甘油三酯、总胆固醇、低密度脂蛋白、血糖、尿酸、同型半胱氨酸、WBC、hs-CRP、VEGF、IL-6等临床指标均明显升高,差异有统计学意义(P均<0.01);进一步Pearson相关分析提示脂肪肝组血清VEGF水平与IL-6、hs-CRP、WBC均呈正相关(r分别为0.602、0.698、0.713,均P<0.01)。结论:NAFLD患者血清VEGF水平明显升高,其水平与IL-6、hs-CRP、WBC等均呈正相关,细胞因子、炎症因子参与了NAFLD的发生发展。Objective：To investigate the correlation between vascular endothelial growth factor and interleukin-6,highsensitivity C-reactive protein,white blood cells count in patients with Nonalcoholic fatty liver disease.Methods：Select the 122 patients with nonalcoholic fatty liver disease（fatty liver group）,108 people with no fatty liver disease（normal control group）were chosen for the study.The related biochemical indices were detected with automatic biochemical analyzer.The levels of serum VEGF and IL-6were measured by Enzyme-linked immunosorbent experiment.The levels of serum hs-CRP were measured by Immune turbidimetry.Results：The comparison of hip circumference（HC）,waist circumference（WC）,body mass index（BMI）,systolic blood pressure（SBP）,diastolic blood pressure（DBP）,alanine aminotransferase（ALT）,aspartate aminotransferase（AST）,total cholesterol（TG）,triglycerides（TC）,low density lipoprotein（LDL-C）,glucose（GLU）,uric acid（UA）,homocysteine（Hcy）,white blood cells count（WBC）,high-sensitivity Creactive protein（hs-CRP）,vascular endothelial growth factor（VEGF）,interleukin-6（IL-6）levels between fatty liver group and normal control group were higher in the fatty liver group than those of normal control group,the difference were significant（all P〈0.01）.Pearson correlation analysis show that serum VEGF levels and IL-6,hs-CRP,WBC were positively correlated in patients with nonalcoholic fatty liver disease（r=0.602,0.698,0.713,all P〈0.01）.Conclusion：The levels of VEGF were significantly increased in nonalcoholic fatty liver disease,it was positively correlated with IL-6,hs-CRP,WBC,suggesting that cytokines and inflammatory cytokines might play an important role in the pathogenesis of nonalcoholic fatty liver disease.

关 键 词：非酒精性脂肪肝 血管内皮生长因子 白介素-6 高敏C反应蛋白 

分 类 号：R575.5[医药卫生—消化系统]