丹红注射液联合依达拉奉在脑梗死患者神经功能恢复中的临床研究  

Research on the neural functional recovery for the patients with cerebral infarction by Danhong injection combine with edaravone

作　　者：马慧[1] 

机构地区：[1]安徽医科大学附属巢湖医院神经内科,巢湖238000

出　　处：《中药药理与临床》2015年第4期284-286,共3页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:探讨丹红注射液联合依达拉奉在脑梗死患者神经功能恢复中的临床疗效。方法:随机抽取2012年3月至2015年1月我院收治的128例脑梗死患者的临床资料,按照随机数字表法将患者均分为实验组和对照组,实验组和对照组患者例数均为64例。患者均进行常规营养支持治疗的同时,加用抗血小板聚集药、脑细胞活化药等,对照组患者采取依达拉奉联合灯盏花素治疗;实验组患者采取丹红注射液、灯盏花素联合依达拉奉治疗,观察两组患者神经功能缺损评分(NIHSS)、神经功能缺损程度评分量表(NDS评分)、临床疗效、不良反应发生情况。结果:实验组患者神经功能缺损评分、NDS评分在治疗后均明显低于对照组和治疗前。对照组患者神经功能缺损评分、NDS评分在治疗后均明显低于治疗前。实验组患者治疗总有效率(90.63%)高于对照组(73.44%),两组患者均未发生严重不良反应。两组患者治疗后IL-6、IL-8、TNF-α、hs CRP、MMP-9水平均明显低于治疗前;实验组患者治疗后IL-6、IL-8、TNF-α、hs CRP、MMP-9水平明显低于对照组。两组患者治疗后TG、TC、LDL-C水平均低于治疗前;实验组患者治疗后TG、TC、LDL-C水平低于对照组,两组患者治疗前后HDL-C水平变化差异无统计学意义。两组患者不良反应发生率比较,差异无统计学意义。结论:丹红注射液、灯盏花素联合依达拉奉在脑梗死患者神经功能恢复中的应用价值较高,可改善患者NIHSS、NDS评分,提高临床疗效,无明显不良反应。Objective： To explore the clinical effects of the neural functional recovery for the patients with cerebral infarction by Danhong injection combine with Edaravone. Methods： 128 cases of patients with cerebral infarction were randomly divided into experiment group（ 64 cases）and control group（ 64 cases）. They were treated by platelet aggregation inhibitor,Brain activation medicine. The control group were treated by Edaravone combine with Breviscapinun. On the basis of the control group,the experiment group were treated by Danhong injection. The scores of NIHSS,NDS,clinical effects,adverse reaction were compared for the two groups. Results： The scores of NIHSS,NDS for the experiment group after treatment were lower than before treatment and control group（ P〈0. 05）; The total effective rate for the experiment group（ 90. 63%） were higher than the control group（ 73. 44%）（ P〈0. 05）; The levels of IL-6,IL-8,TNF-α,hs CRP,MMP-9 after treatment for the two groups were lower than before treatment（ P〈0. 05）; The levels of IL-6,IL-8,TNF-α,hs CRP,MMP-9 after treatment for the experiment group were lower than the control group（ P〈0. 05）; The levels of TG,TC,LDL-C after treatment for the two groups were lower than before treatment（ P〈0. 05）; The levels of TG,TC,LDL-C after treatment for the experiment group were lower than the control group（ P 0.05）; There has no significant difference on the levels of HDL-C（ P〈0. 05）. There has no significant difference on the adverse reaction for the two groups（ P〉0. 05）. Conclusion： It has high values of the neural functional recovery for the patients with cerebral infarction by Danhong injection,Dengzhanhuasu combine with Edaravone,it can improve the scores of NIHSS,NDS,it can increase the clinical effects,with no adverse reaction.

关 键 词：丹红注射液 灯盏花素 依达拉奉 脑梗死 神经功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]