抑郁症是一种炎性疾病吗?——介绍抑郁症的神经炎性反应假说  

Depression is an inflammatory disease?——Introduce nerve inflammation hypothesis of depression

作　　者：黄庆军[1] 许崇涛[1] 

机构地区：[1]汕头大学精神卫生中心,汕头515041

出　　处：《转化医学研究（电子版）》2014年第4期88-94,共7页Translational Medicine Research(Electronic Edition)

摘　　要：抑郁症(depression)是一种严重影响人类健康的高发精神疾病,其发病机制尚不清楚。单胺类神经递质假说是被广泛接受的抑郁症发病的生物学机制之一,但以此研发的抗抑郁药物存在起效慢、有效率低的缺点。越来越多的证据表明,炎性反应过程参与抑郁症的发病。目前抑郁症的诊断主要依靠症状学,因此抑郁症可能是症状相同的一类疾病,其中存在一种"炎性亚型",其特征是患者存在高炎性状态。本文从脑内炎细胞因子、神经胶质细胞及其神经生物学作用与抑郁症的关系综述了抑郁症发病的炎性机制,探讨抗感染治疗抑郁症的可能性。Depression is a severe mental disorder with a high prevalence and its pathogenesis is not fully understood.Of the proposed hypotheses about depression,monoamine hypothesis is being commonly accepted.The hypothesis-driven antidepressants,however,take their efiects after a relatively long-term,and produce no efficacy in some patients.There is increasing evidence for the involvement of neuroinflammation in the pathogenesis of depression.The diagnosis of depression is mainly based on the clinical manifestations composed of a variety of symptoms,which may be considered as the phenotypes of a class of mental disorders.Of the depression patients,some are characterized with high levels of inflammatory factors and can be classified the ＂inflammatory subtype＂ of depression.This article reviewed the recent findings of proinflammation cytokines and neuroglia in depression patients and animal models of it,discussed the neurobiological actions of these inflammatory factors in the pathogenesis of depression,and explored the possible anti-inflammation strategies for the treatment of depression.

关 键 词：抑郁症 单胺 神经递质 炎性反应 细胞因子 

分 类 号：R749.4[医药卫生—神经病学与精神病学]