URG4在卵巢恶性上皮性肿瘤中的表达及临床病理意义  

Expression and clinicopathological significance of URG4 in epithelial ovarian carcinoma

作　　者：贾朝阳[1] 刘巍[1] 谭文华[1] 

机构地区：[1]哈尔滨医科大学附属第二医院妇产科,150081

出　　处：《国际遗传学杂志》2015年第5期237-241,286,共6页International Journal of Genetics

摘　　要：目的探讨上调基因-4（URG4）在卵巢恶性上皮性肿瘤中的表达及其与各临床病理特征之间的关系。方法采用免疫组化的方法检测50例卵巢恶性上皮性肿瘤组织、20例卵巢良性肿瘤组织、20例正常卵巢组织标本中URG4的表达情况，分析URG4的表达与各临床变量之间的关系。结果卵巢恶性上皮性肿瘤组织中URG4主要表达于细胞浆中，呈现散在或弥散的棕黄色颗粒。URG4在卵巢恶性上皮性肿瘤组织中的阳性表达率（86％）高于卵巢良性肿瘤组织（40％）和正常卵巢组织（15％），差异具有统计学意义（X2=15．286，P〈0．05；X2=31．963，P〈0．05）。在不同年龄组及不同组织学类型的卵巢恶性上皮性肿瘤组织中。URG4的表达差异无统计学意义（X2=0．166，P〉0．05；X2=0．603，P〉0．05）；随着卵巢恶性上皮性肿瘤组织的临床期别、病理分级愈高，URG4的阳性表达也愈强，差异具有统计学意义（X2=8．449，P〈0．05；X2=11．589，P〈0．05），且有淋巴结转移者URG4的表达高于无淋巴结转移者，腹水中肿瘤细胞阳性者URG4的表达高于腹水中无肿瘤细胞者，差异具有统计学意义（X2=4．578，P〈0．05；X2=13．445，P〈0．05）。结论与卵巢良性肿瘤及正常卵巢组织相比，URG4在卵巢恶性上皮性肿瘤组织中表达增高；URG4阳性表达率与卵巢恶性上皮性肿瘤组织的临床分期、病理分级：淋巴结转移及腹水中癌细胞呈正相关，但与患者年龄及组织学类型相关无统计学意义。高表达的URG4可能在卵巢恶性上皮性肿瘤的发生、发展过程中起重要的作用。Objective To investigate the expression of URG4 in epithelial ovarian carcinoma and the clinicopathologieal significance. Methods Immunohistochemical method was used to detect the expression of URG4 in 50 cases of epithelial ovarian carcinoma, 20 cases of benign ovarian tumor tissues and 20 cases of normal ovarian tissues. We analyzed the relationship between the expression of URG4 and clinical variables. Results In epithelial ovarian carcinoma, URG4-positive staining was shown as seattered or diffuse brown particles in cytoplasm. The expression rate of URG4 in 50 cases of epithelial ovarian carcinoma was 86% , which is signifieantly higher than that in 20 cases of benign overian tumor （40% ,X2 =15.286, P〈0.05） and20 cases of normal ovarian tissue （15% ,X2 =31 963, P〈 0.05 ）. In different age groups and different histological types of epithelial ovarian cancer tissues, the differences in the expression of URG4 were not statistically significant （X2 = 0. 166, P 〉 0.05 and X2 = 0. 603 , P 〉 0.05 ,respeetively ） . With in creases in elinical stage and the pathological grade of epithelial ovarian carcinoma tissues, the expression of URG4 became stronger, and the differences were significant （X2 = 8. 449, P 〈 0.05 ; X2 = 11. 589, P 〈 0. 05 ） . Moreover, the expression of URG4 in the patients with lymph node metastasis and with ascetic tumor ceils was significantly higher than those without （X2 = 4.578, P 〈 0.05 and X2 = 13.445 , P 〈 0.05 ,respeetively ） . Conclusion Compared with benign ovarian tumors and normal ovarian tissues, the URG4 was over-expressed in epithelial ovarian carcinoma. In epithelial ovarian carcinoma, the expression of URG4 was positively correlated with clinical stage, pathological grade, lymphatic-metastasis and ascetie tumor cells, however, it had no correlation with age and histological type. Thus the overexpression of URG4 may play an important role in the occurrenee and development of epithelial ovarian earcinoma.

关 键 词：上调基因-4 癌基因 卵巢恶性上皮性肿瘤 免疫组化 

分 类 号：R737.31[医药卫生—肿瘤]