胃底腺息肉临床病理特征分析  

Analysis of clinico pathological features in fundic gland polyps

作　　者：马毓梅[1] 阮联英[2] 张杰英[1] 

机构地区：[1]河北医科大学第二医院病理科,河北石家庄050000 [2]邢台市人民医院儿科,河北邢台054031

出　　处：《临床荟萃》2015年第10期1167-1169,共3页Clinical Focus

基　　金：河北省科技支撑计划(09276102D-3)

摘　　要：目的观察胃底腺息肉(FGPs)的临床病理特征及β-连接素和周期素D1蛋白的表达特点。方法分析200例FGPs临床病理特点,免疫组织化学方法检测β-连接素和CyclinD1蛋白的表达。结果 500例胃息肉患者中,女性与男性FGPs发病率比较差异有统计学意义(χ2=74.630,P<0.01),男女患者平均年龄比较差异有统计学意义(t=15.690,P<0.01)。FGPs多位于胃底或胃体,直径多小于5mm。免疫组织化学染色均可见细胞膜β-连接素强表达,细胞核未见表达。细胞浆或细胞核均未见周期素D1表达。结论 FGPs患者中女性多见,未发现存在β-连接素突变和周期素D1异常表达,恶性潜能低。Objective To explore the clinicopathological characteristics,and the expression ofβ-catenin,and cyclin D1 in fundic gland polyps.Methods Clinicopathological features of 200 cases of fundic gland polyps were analyzed.Immunohistochemistry staining was used to detectβ-catenin and cyclin D1 expression in 50 cases of fundic gland polyps.Results Among 500 cases of gastric polyps,the incidence of men and women showed significant difference（χ2=74.630,P 0.01）.The average age of men and women had significant difference,too（t=15.690,P0.01）.And fundic gland polyps were more located in the bottom of the stomach or gastric body,less than 5mm in diameter.The strong expression ofβ-catenin in 50 cases of fundic gland polyps was all located in the cell membrane,and noβ-catenin nucleus expression in 50 cases of fundic gland polyps.Negative expression of cycle D1 was also observed.Conclusion In fundic gland polyps patients,the majority are females.β-catenin mutation,and cycle D1 abnomal expression were not found in fundic gland polyps.Fundic gland polyps has low malignant potential.

关 键 词：腺瘤性息肉 免疫组织化学 Β-连接素 周期素D1 

分 类 号：R730.261[医药卫生—肿瘤]