微RNA-7在肿瘤中的生物学作用及其临床应用前景  

Biological Function of MicroRNA-7 in Cancer and Its Clinical Potential

作　　者：江明杰[1] 代娟娟[1] 付迪[1] 田聆[1] 

机构地区：[1]上海交通大学附属第一人民医院实验中心,上海201620

出　　处：《医学综述》2015年第21期3899-3902,共4页Medical Recapitulate

基　　金：国家自然科学基金面上项目(81172030);上海交通大学医学院大学生创新训练项目(2014059)

摘　　要：微RNA-7(miR-7)是23个核苷酸长的非编码小分子RNA,其在多种肿瘤组织中的表达降低,与肿瘤生长、转移等密切相关。miR-7作为一个肿瘤抑制因子,可抑制表皮生长因子受体、胰岛素样生长因子1受体等基因的表达,从而抑制肿瘤的发生、发展。此外,miR-7还能提高肿瘤对化疗的敏感性,并抑制肿瘤血管生成。miR-7本身也受细胞内复杂机制的调控,其表达量变化及其对肿瘤的调控可为肿瘤的诊治提供新思路,具有良好的潜在临床应用前景。MicroRNA-7（miR-7） is a 23-nucleartide small non-coding RNA whose expression is down- regulated in various cancers and has been linked to cancer growth as well as metastasis. Acting as a tumor suppressor ,miR-7 can suppress tumor growth via inhibiting the expression of critical genes such as epidermal growth factor receptor, insulin-like growth factor-1 receptor. Meanwhile, miR-7 can also inhibit tumor anglo- genesis and promote its sensitivity to chemotherapy. In addition, miR-7 itself is regulated by some complex intraeellular mechanisms. Based on its changed expression and its role in regulating cancer development, miR-7 shows potential clinical applications in cancer diagnosis and therapy.

关 键 词：微RNA-7 肿瘤生物学 表达调控 肿瘤治疗 

分 类 号：R730.2[医药卫生—肿瘤]