进展期胃癌术前区域动脉灌注化疗的研究进展  

Research Progress of Preoperative Regional-Arterial Chemotherapy in Advanced Gastric Cancer

作　　者：李振凯[1] 董茂盛[1] 

机构地区：[1]中国人民解放军第二炮兵总医院普通外科,北京100088

出　　处：《中国普外基础与临床杂志》2015年第11期1410-1415,共6页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的总结进展期胃癌术前区域动脉灌注化疗的研究进展。方法对有关进展期胃癌术前区域动脉灌注化疗研究进展的文献进行综述。结果进展期胃癌术前区域动脉灌注化疗可显著降低肿瘤分期,提高R0切除率,提高远期生存率;可有效提高肿瘤及门静脉的药物浓度,既可直接杀伤、破坏癌细胞,还可有效防治肝及淋巴结转移,并可减少毒副作用;动脉灌注化疗短时间内就可导致癌细胞核发生固缩和碎裂;进展期胃癌术前区域动脉灌注化疗时间一般为4~9周,然后根据疗效评价结果进一步决定是否行手术治疗。结论进展期胃癌术前区域动脉灌注化疗理论上较静脉全身化疗更有优势,进一步多中心、大型的临床试验的深入研究可能会为其开辟更为广阔的应用前景。Objective To summarize the research progress of preoperative regional-arterial chemotherapy in advanced gastric cancer.Method The literatures about the research progress of preoperative regional-arterial chemotherapy in the advanced gastric cancer were reviewed.Results The preoperative regional-arterial chemotherapy in the advanced gastric cancer could decrease the tumour stage,improve the RO resection rate and the long-term survival rate,effectively improve the drug concentrations of tumor and portal vein,and not only kill or damage cancer cells directly,but also prevent the metastasis of liver and lymph nodes effectively,and reduce the side effects,cause the nuclear pyknosis and fracture of cancer cells in a short time.The course of preoperative regional-arterial chemotherapy in the advanced gastric cancer generally was 4- 9 weeks,and then whether the surgery treatment was decided to undergo according to the results of the curative effect evaluation.Conclusions The preoperative regional-arterial chemotherapy in the advanced gastric cancer has more advantages than intravenous chemotherapy,further research of multicenter and large clinical trials,would inaugurate a wider application prospects.

关 键 词：进展期胃癌 术前区域动脉灌注化疗 

分 类 号：R735.2[医药卫生—肿瘤]