SUMO化修饰系统及其在肿瘤发展中的作用  

SUMOylation and Its Role in Tumor Development

作　　者：张梅[1,2] 王淼[1] 伍会健[1] 

机构地区：[1]大连理工大学生命科学与技术学院,大连116024 [2]黑龙江中医药大学生物化学与分子生物学教研室,哈尔滨150040

出　　处：《中国细胞生物学学报》2015年第10期1458-1464,共7页Chinese Journal of Cell Biology

基　　金：国家青年自然基金(批准号:81301504);国家重点基础研究发展计划(973计划)(批准号:2011CB504201);黑龙江省留学归国科学基金(批准号:LC2015032);黑龙江中医药大学博士创新基金(批准号:2013bs01)资助的课题~~

摘　　要：小泛素相关修饰物(small ubiquitin-related modifier,SUMO)修饰是一种动态可逆的蛋白质翻译后修饰方式,SUMO蛋白可以共价结合到靶蛋白上。目前,在哺乳动物中,已经鉴定出4种不同的SUMO蛋白亚型,分别是SUMO-1、SUMO-2、SUMO-3和SUMO-4。SUMO化修饰对靶蛋白的功能具有重要的调节作用,如蛋白质的稳定性、亚细胞定位、信号转导、基因转录调控等。最新的研究表明,SUMO化修饰与肿瘤的发生、发展密切相关,但具体的机制还不清楚。该文就SUMO化修饰在肿瘤发展过程中作用机制的最新研究进展作一综述。SUMOylation is a kind of reversible and highly dynamic post-translational modification of proteins, which could covalently bind SUMO （small ubiquitin-related modifier） to target proteins or remove from target proteins. Currently, four different isoforms, known as SUMO-1, SUMO-2, SUMO-3 and SUMO-4, have been identified in mammals. SUMOylation plays important roles in the regulation of protein functions, such as the stability of proteins, subcellular location, signal transduction and gene transcriptional regulation. Recent studies demonstrate that SUMOylation is closely related to the initiation and the development of tumor. However, the detailed mechanism is still inconclusive. This review will focuse on the possible implications of SUMOylation in the development of tumor.

关 键 词：小泛素相关修饰物 肿瘤 泛素 

分 类 号：R730.2[医药卫生—肿瘤]