癌胚抗原及糖链抗原199与直肠癌临床病理特征及预后的相关性  

Relationship among CEA, CA199, clinical pathological characteristics and prognosis in patients with rectal cancer

作　　者：赵鹏飞[1] 李琴[1] 曹邦伟[1] 

机构地区：[1]首都医科大学附属北京友谊医院肿瘤科,北京市100050

出　　处：《实用医学杂志》2015年第20期3304-3307,共4页The Journal of Practical Medicine

基　　金：国家自然科学基金(编号:81272615;81301912);北京市卫生系统高层次卫生技术人才项目(编号:2011-3-00)

摘　　要：目的：探讨术前癌胚抗原（CEA）及糖链抗原199（CA199）与直肠癌的临床病理特征及预后的相关性。方法：选取首都医科大学附属北京友谊医院2006年1月至2010年12月共142例因直肠癌行手术切除的患者，随访42-90个月。分析术前CEA及CA199与性别、年龄、浸润深度、淋巴结转移等临床病理特征的相关性及与无疾病进展时间和总生存时间（overall survival，OS）的相关性。结果：术前CEA水平升高与发生远处脏器转移显著相关（P ＜0．05）；术前CEA和CA199均正常组，中位OS为150周，术前CEA 和（或） CA199异常组，中位OS为101周，生存分析结果显示术前CEA和CA199均正常组患者OS比CEA和（或） CA199异常组显著延长，两组比较差异有统计学意义（P ＝0．031）。结论：直肠癌术前CEA水平可以预测远处脏器转移情况，术前CEA和（或）CA199异常组患者总生存时间更短。Objective To investigate the relationship among CEA, CA199, clinical pathological characteristics and prognosis in patients with rectal cancer. Methods A total of 142 patients diagnosed rectal cancer were collected for the study between January 2006 and December 2010. The clinical data including age, sex, size of tumor, differentiation, depth of tumor （T）, lymph node metastasis （N）, distant metastasis （M）, lymphatic invasion, venous invasion, stage, and preoperative serum levels of CEA and CA199 were obtained. Patients′ follow-up ranged from 42 months to 90 months. Results Preoperative elevated CEA levels were significantly associated with distant metastasis （P 〈 0.05）. Median overall survival time was 150 weeks in the group with normal preoperative CEA and CA199, and 101 weeks in the group with preoperative abnormal preoperative CEA and/or CA199, and Kaplan-Meier analysis showed that the difference was significant between two groups （P = 0.031）. Conclusion Elevated preoperative CEA level can predict distant metastasis. The patients with abnormal preoperative CEA and/or CA199 have shorter overall survival time.

关 键 词：直肠肿瘤 CA199 病理特征 预后 

分 类 号：R735.37[医药卫生—肿瘤]