β-环糊精-丙磺酸催化合成14-烷基(芳基)-14H-二苯并[a,j]氧杂蒽衍生物  

Synthesis of 14-Alkyl- or Aryl-14H-Dibenzo[a,j]xanthenes Catalyzed by β-Cyclodextrin-Propyl Sulfonic Acid

作　　者：巩凯[1] 韩毅[1] 李玲[1] 陈敬华[1] 

机构地区：[1]江南大学药学院,江苏无锡214122

出　　处：《精细化工》2015年第11期1255-1259,共5页Fine Chemicals

基　　金：国家自然科学基金(51303069)~~

摘　　要：以β-环糊精（β-CD）为原料,在氢氧化钠水溶液中与1,3-丙磺酸内酯反应得到磺酸丙基醚-β-环糊精,再经阳离子交换树脂得到催化剂β-环糊精-丙磺酸（β-CD-PSA）。以苯甲醛和β-萘酚的缩合反应为模板反应,探讨反应温度、催化剂用量对反应的影响并优化工艺条件。以β-CD-PSA/H2O为催化体系,制备了一系列14-烷基（芳基）-14H-二苯并[a,j]氧杂蒽衍生物,β-CD-PSA用量为1%（摩尔分数）,反应温度为100℃,反应时间为6~60 min,反应产率为85%~95%。催化剂具有良好的循环使用性能,至少循环使用10次,其催化活性未明显降低。β-CD was reacted with 1,3-propane sultone in Na OH solution to afford sulfopropyl ether β-cyclodextrin,and subsequently,it was further treated with acidic resin to give β-cyclodextrin-propyl sulfonic acid（ β-CD-PSA）. In order to optimize the conditions,the condensation reaction of benzaldehyde and β-naphthol was examined in presence of different amounts of β-CD-PSA under various reaction conditions. A series of 14-alkyl- or aryl-14H-dibenzo[a,j]xanthenes were synthesized in presence of 1%（ molar ratio） of β-CD-PSA,in water at 100 ℃ to afford the corresponding compounds ratio of 85%- 95% within 6- 60 min. The catalyst can be reusable. It could be reused tentimes without a significant loss of catalytic activity.

关 键 词：Β-环糊精 酸催化 缩合反应 氧杂蒽衍生物 催化与分离提纯技术 

分 类 号：O643[理学—物理化学]