银杏达莫注射液用于高血压脑出血微创术后神经功能恢复的临床观察  

Clinical Observation of the Effects of Yinxing Damo Injection on Recovery of Neural Function after Hypertension Intracerebral Hemorrhage Minimally Invasive Surgery

作　　者：管静静[1] 赵冠安 张学磊[2] 王双虎[1] 吴春美[1] 

机构地区：[1]丽水市人民医院药剂科,浙江丽水323000 [2]丽水市人民医院急诊科,浙江丽水323000

出　　处：《中国药房》2015年第32期4526-4528,共3页China Pharmacy

基　　金：浙江省中西医结合学会临床药学科研基金(康恩贝专项)(No.2014LYK007)

摘　　要：目的:观察银杏达莫注射液对高血压脑出血(HICH)微创术后神经功能恢复的疗效及安全性。方法:选取HICH患者84例,按随机数字表法分为对照组和观察组,各42例。两组患者均CT引导下行微创碎吸术,对照组患者术后给予脱水降颅压、控制血压、防治感染、营养神经等西医基础治疗;观察组患者在西医治疗基础上加用银杏达莫注射液20 ml,ivgtt,bid。两组患者疗程均为14 d。两组患者治疗前后进行美国国立卫生院神经功能缺损(NIHSS)评分、格拉斯哥昏迷(GCS)评分和Fugl-Meyer运动功能评价量表评分;检测两组患者治疗前后血浆神经元特异性烯醇化酶(NSE)和血清补体C3、C4及超敏C反应蛋白(hs-CRP)水平。结果:治疗后,观察组的有效率(85.71%)优于对照组(66.67%),差异有统计学意义(P<0.05);两组患者NIHSS、Fugl-Meyer、GCS评分均优于治疗前,且观察组优于对照组,观察组患者血清补体C3、C4水平低于对照组,差异有统计学意义(P<0.01)。仅观察组患者出现1例过敏反应,给予硫酸镁外敷缓解,未影响治疗。结论:银杏达莫注射液能改善神经缺损功能,促进患者神经功能的恢复,安全性较好。OBJECTIVE： To observe therapeutic efficacy and safety of Yinxing damo injection for neural function recovery af- ter hypertensive intracerebral hemorrhage （HICH） minimally invasive surgery. METHODS： 84 HICH patients were randomly di- vided into control group and observation group with 42 patients in each group. Both groups received CT guiding minimally inva- sive aspiration. Control group was given western medicine baseline therapy, such as dehydration and intracranial decompression, controlling blood pressure, preventing infection, alimenting never, symptomatic treatment. Observation group was additionally giv- en Yinxing damo injection 20 ml, ivgtt, bid. Treatment course lasted for 14 d. NIHSS score, GCS score and Fugl-Meyer motor function assessment scale score were eomducted before and after treatment. The serum levels of NSE, serum C3, C4 and hs-CRP were determined in 2 groups before and after treatment. RESULTS： After treatment, the effective rate of observation group （85.71%） was better than that of control group （66.67%）, with statistical significance （P〈0.05） ; after treatment, NIHSS score, Fugl-Meyer score and GCS score of 2 groups were all better than before, the observation group was better than the control group, the levels of C3 and C4 in observation group were lower than in control group, with statistical significance （P〈0.01）. There was one case of allergic reaction that the patient can tolerate. Magnesium sulfate for external use was given, which did not affect the treatment. CONCLUSIONS： Yinxing damo injection could improve neurologic impairment, promote the recovery of patients and have good safety.

关 键 词：高血压脑出血 银杏达莫注射液 神经元特异性烯醇化酶 血清补体C3、C4 超敏C反应蛋白 

分 类 号：R743.2[医药卫生—神经病学与精神病学]