西酞普兰治疗脑卒中抑郁症的疗效观察  

Efficacy Observation of Citalopram in the Treatment of Post-stroke Depression

作　　者：高晨 

机构地区：[1]锦州市康宁医院,辽宁锦州121000

出　　处：《中国药房》2015年第32期4572-4574,共3页China Pharmacy

摘　　要：目的:观察西酞普兰治疗脑卒中抑郁症患者的疗效。方法:选取脑卒中抑郁症患者126例,按随机数字表法分为观察组和对照组,各63例。对照组患者给予神经系统药物常规治疗,观察组患者在对照组基础上给予西酞普兰,20 mg,qd,早餐后服用。均持续治疗2个月。观察两组患者治疗前后精神状况,血浆P物质(SP)、血浆促肾上腺皮质激素释放激素(CRH)、血浆神经肽Y(NPY)水平及患者康复依从性。结果:治疗后,观察组患者汉密顿抑郁量表(HAMD)与美国国立卫生研究院卒中量表(NIHSS)评分明显降低,且低于对照组,差异有统计学意义(P<0.05);观察组患者简易精神状态检查表(MMSE)评分显著升高,且高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者SP、CRH水平明显降低,且低于对照组;NPY水平明显升高,且高于对照组,差异均有统计学意义(P<0.05);治疗后,观察组患者完全依从比例(71.43%)明显高于对照组(49.21%),差异有统计学意义(P<0.05)。观察组患者治疗各时期的疗效均好于对照组,差异有统计学意义(P<0.05)。结论:西酞普兰治疗脑卒中抑郁症患者,可明显改善患者抑郁状态、神经功能,并提高患者康复依从性,疗效显著。OBJECTIVE ： To observe therapeutic efficacy of citalopram in the treatment of post-stroke depression. METHODS ： 126 post-stroke depression patient were selected and randomly divided into observation group and control group with 63 cases in each group. Control group was given routine treatment of nervous system drugs; observation group was given citalopram, 20 rag, qd, after breakfast, on the basis of control group.They were given relevant medicine for consecutive 2 months. The mental status, the levels of plasma substance P （SP）, plasma adrenocorticotropic hormone releasing hormone （CRH） plasma neuropeptide Y （NPY）, rehabilitation compliance were observed in 2 groups before and after treatment. RESULTS： After treatment, HAMD and NIHSS score of observation group were decreased obviously, and lower than control group, with statistical significance （P〈 0.05） ; MMSE score of observation group increased significantly, and higher than control group, with statistical significance （P〈 0.05）. After treatment, SP and CRH levels of observation group were decreased significantly, and lower than control group; NPY level increased significantly and higher than control group, with statistical significance （P〈0.05）. After treatment, complete com- pliance of observation group （71.43%） was obviously higher than that of control group （49.21%）, with statistical significance （P〈0.05）. The maximum effect of observation group was significantly better than that of control group, with statistical signifi- cance （P〈0.05）. CONCLUSIONS： Citalopram in the treatment of post-stroke depression can significantly improve the patients＇ de- pression, nervous function and rehabilitation compliance of patient, showing significant therapeutic efficacy.

关 键 词：脑卒中 抑郁症 西酞普兰 康复依从性 美国国立卫生研究院卒中量表 

分 类 号：R749.13[医药卫生—神经病学与精神病学]