非小细胞肺癌患者甲状腺激素水平与临床分期的相关性  

Correlation between thyroid hormone levels and clinical staging in patients with non-small cell lung cancer

作　　者：原春玲[1] 梁嵘[1] 林燕[1] 张玉梅[1] 黎倩[1] 梁超勇[1] 李永强[1] 

机构地区：[1]广西医科大学附属肿瘤医院消化肿瘤内科,南宁530021

出　　处：《中国癌症防治杂志》2015年第5期347-350,共4页CHINESE JOURNAL OF ONCOLOGY PREVENTION AND TREATMENT

摘　　要：目的研究非小细胞肺癌(non—small cell lung cancer,NSCLC)患者甲状腺激素水平与临床分期的相关性,为临床评估NSCLC患者的疴情及临床预后提供参考,以指导临床治疗。方法收集80例NSCLC患者(NSCLC组)、40例其他类型恶性肿瘤患者(其他类型组)、30名健康人(正常对照组)的临床资料,对照分析3组的血清甲状腺激素水平和不同分期NSCLC患者的甲状腺激素水平。结果随着NSCLC临床分期的升高,总三碘甲状腺原氨酸(TT_3)和游离三碘甲状腺原氨酸(FT_3)水平显著下降(P<0.05),而总甲状腺素(TT_4)、游离甲状腺素(FT_4)以及促甲状腺激素(TSH)水平的差异无统计学意义(P>0.05)。其他类型组和正常对照组的TT_3、FT_3及FT_4水平均显著高于NSCLC组(P<0.05),TT_4及TsH水平3组之间无明显差异(P>0.05),正常对照组的TT_3水平显著高于其他类型组(P<0.05)。结论 NSCLC患者的甲状腺激素水平显著改变,且与临床分期存在密切关系,监测甲状腺激素水平可为临床评估患者的病情提供参考。Objective To examine possible correlation between thyroid hormone levels and clinical stage in patients with non- small cell lung cancer （NSCLC）, and to provide guidelines for using levels to evaluate patients and design treatments. Methods Serum levels of thyroid hormones were compared for 80 patients with NSCLC, 40 patients with other types of malignant tumor,and 30 healthy controls. Results Levels of TT3 and FT3 decreased significantly with increasing NSCLC stage （P〈0.05）, while levels of TT4,FT4 and TSH did not vary significantly with stage （P〉0.05）. Levels of FT4, FT3 and TT3 were significantly lower in the NSCLC group than in the other two groups （P〈0.05）, while levels of TT4 and TSH were similar across all three groups （P〉0.05）. Levels of TT3 were significantly higher in the control group than in the other two groups （P〈0.05）. Conclusion NSCLC is associated with significant changes in thyroid hormone levels, which correlate with clinical stage. Monitoring these hormone levels in patients may help guide their evaluation and treatment.

关 键 词：肺肿瘤 甲状腺激素 临床分期 相关性 

分 类 号：R734.2[医药卫生—肿瘤]