GRP及GRPR在结直肠癌中的表达及意义  

Expression and significance of GRP and GRPR in colorectal cancer

作　　者：廖江涛 李娟 陈银芸 

机构地区：[1]湖南省老年医院消化内科,长沙410016

出　　处：《中国当代医药》2015年第30期7-10,共4页China Modern Medicine

基　　金：湖南省科学技术厅科技计划一般项目(2012FJ3076)

摘　　要：目的探讨胃泌素释放肽(GRP)、胃泌素释放肽受体(GRPR)在结直肠癌中的表达,为结直肠癌的治疗提供依据。方法选取我院收治的64例结直肠癌患者作为研究对象,收集其系统的资料,利用免疫组化技术了解患者GRP、GRPR蛋白的表达,分析结直肠癌中GRP与预后、远处转移的关系及其灵敏度、特异度。结果 GRP、GRPR蛋白在结直肠癌组织中阳性表达率分别为76.56%和89.06%,两者表达呈正相关。GRP、GRPR能够在一定程度上预测结直肠癌远处转移,灵敏度及特异度为68.7%、70.5%及69.8%、66.7%。结论 GRP和GRPR在结直肠癌中表达明显,可以作为结直肠癌的早期预测指标,并可能通过干预两者的表达成为治疗结肠癌的靶点。Objective To explore the expression of gastrin releasing peptide （GRP） and its receptors （GRPR） in col-orectal cancer,and to provide basis for treatment of colorectal cancer. Methods 64 patients with colorectal cancer treat-ed in our hospital were selected and their systematic materials were collected.The expression of GRP and GRPR was detected by immunohistochemistry technology and the relation between GRP and the prognosis and distant metastasis of colorectal cancer as well as its sensibility and specificity were analyzed. Results The positive expression rates of GRP and GRPR in colorectal cancer tissue were 76.56% and 89.06%,respectively,which were positively associated.GRP and GRPR could partly predict the distant metastasis of colorectal cancer,with sensibility and specificity as 68.7%,70.5%and 69.8%,66.7%. Conclusion There is evident expression of GRP and GRPR in colorectal cancer,which can be used as early predictors of colorectal cancer;and intervention of GRP and GRPR expression is a potential target in treatment of colorectal cancer.

关 键 词：胃泌素释放肽 胃泌素释放肽受体 结直肠癌 

分 类 号：R735.3[医药卫生—肿瘤]