咪达那新合成工艺的改进  

Improvement on the synthesis process of Imidafenacin

作　　者：王蕾[1] 石权达 

机构地区：[1]沈阳津昌制药有限公司,沈阳110179 [2]辽宁亿灵科创生物医药科技有限公司,本溪117004

出　　处：《北方药学》2015年第11期80-81,共2页Journal of North Pharmacy

摘　　要：目的:对咪达那新的合成工艺进行改进。方法:以二苯乙腈为起始原料,经缩合1、缩合2及水解得到目标产物。结果:经三步合成了目标产物,总收率为68%,目标化合物结构经1HNMR和MS确证。结论:本合成方法原料易得,反应条件温和,适合工业化生产。Objective： To improve the synthesis process of Imidafenacin. Methods： Starting with diphenylacetonitrile, the target compound was prepared through a three-step procedure including condensation 1,condensation 2 and hydrolysis reaction. Results：The target compound was obtained in an overall yield of 68%. The structure of target compound was confirmed by 1HNMR and MS.Conclusion：The optimized process with easily purchased materials,facile reaction conditions and convenient operation procedures promises a scale-up manufacture.

关 键 词：咪达那新 二苯乙腈 合成 

分 类 号：R914[医药卫生—药物化学]