氟比洛芬酯注射液联合硫酸吗啡缓释片治疗中、重度癌痛患者的效果分析  

Effect of flurbiprofen axetil injection combined with morphine sulfate sustained release tablets in the tr-eatment of patients with moderate or severe cancer pain

作　　者：张昆[1] 邹梅[1] 张蓉[1] 韩智晓[1] 苏相飞 

机构地区：[1]中山大学孙逸仙纪念医院麻醉科,广州510120

出　　处：《中国医学前沿杂志（电子版）》2015年第9期124-127,共4页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的研究氟比洛芬酯注射液联合硫酸吗啡缓释片对中、重度癌痛患者疼痛及生活质量的影响。方法将本院94例中、重度癌痛患者随机分为观察组及对照组。观察组患者采取氟比洛芬酯联合硫酸吗啡缓释片治疗,对照组患者采取硫酸吗啡缓释片治疗。比较治疗后两组患者视觉模拟评分法(VAS)评分、欧洲癌症研究与治疗组织生活质量测定量表(EORTC QLQ-C30)评分及不良反应发生情况。结果治疗后观察组患者VAS评分明显低于对照组(P<0.01),疼痛控制率明显高于对照组(P<0.05)。两组患者EORTC QLQ-C30评分比较,观察组患者功能量表5项评分均高于对照组(P<0.05),且症状量表及单一症状量表中疼痛及失眠项目评分均低于对照组(P<0.01),总体健康量表评分明显高于对照组(P<0.01)。两组患者不良反应发生率比较无明显差异(P>0.05)。结论氟比洛芬酯注射液联合硫酸吗啡缓释片可有效改善中、重度癌痛患者的临床症状,提高患者生存质量,且不增加不良反应。ObjectiveTo explore the influence of flurbiprofen axetil injection combined with morphine sulfate sustained release tablets in the treatment of patients with moderate or severe cancer pain.Method 94 patients with moderate or severe cancer pain in our hospital were randomly divided into observation group and control group. Patients in observation group were treated with flurbiprofen axetil injection combined with morphine sulfate sustained release tablets, patients in control group were treated with morphine sulfate sustained release tablets. VAS and EORTC QLQ-C30 scores and the occurrence of untoward effect between the two groups after treatment were compared.ResultAfter treatment, VAS scores of observation group were obviously lower than control group （P〈0.01）; pain control rate of observation group was higher than control group （P〈0.05）. When the treatment was ifnished, observation group had higher scores than control group in the 5 items of functioning scale （P〈0.05）, and the scores of pain and insomnia in observation group were both lower than control group （P〈0.01）; observation group had obviously higher score than control group in general health questionnaire （P〈0.01）; there was not signiifcant difference between the two groups in occurrence of untoward effect （P〉0.05）.ConclusionFlurbiprofen axetil injection combined with morphine sulfate sustained release tablets can effectively relieve clinlcal symptom of patients with moderate or severe cancer pain, improvethe quality of life, and it does not increase the untoward effect.

关 键 词：氟比洛芬酯注射液 硫酸吗啡缓释片 癌痛 

分 类 号：R730.5[医药卫生—肿瘤]