非小细胞肺癌CT灌注成像与微淋巴管生成的关系  

Relationship Between CT Perfusion Imaging and the Generation of Micro Lymphatic Vessels in Non-small Cell Lung Cancer

作　　者：樊涛 韩琴芳 潘历波 赵学武 王曙生 郭利锋 

机构地区：[1]陕西省肿瘤医院CT室,陕西西安710061 [2]陕西省肿瘤医院肿瘤外科,陕西西安710061

出　　处：《中国医学影像学杂志》2015年第9期674-676,681,共4页Chinese Journal of Medical Imaging

基　　金：陕西省科学技术研究发展计划项目(2011K12-05-04)

摘　　要：目的 CT灌注成像参数与肺癌的病理类型及微血管生成有一定的关系,为进一步判断CT灌注成像参数评价肺癌临床预后的价值,本文探讨非小细胞肺癌(NSCLC)CT灌注成像参数血容量(BV)、血流量(BF)、对比剂到达峰值时间(TTP)和强化峰值(PEI)与微淋巴管密度(MLVD)的关系。资料与方法 100例肺内单发结节患者行CT灌注扫描,其中60例经病理证实为NSCLC,采用免疫组化法观察60例NSCLC患者的MLVD表达,分析NSCLC患者CT灌注参数与MLVD表达的关系。结果 NSCLC患者MLVD在肺癌边缘组织分布最多(25.16±1.28),其次为肺癌中心组织(16.38±3.58),在正常肺组织中分布最少(7.56±4.38),差异有统计学意义(P<0.05)。肿瘤BF、BV与肿瘤MLVD计数呈正相关(r=0.643、0.598,P<0.01)。结论 CT灌注成像参数BF、BV与NSCLC患者肿瘤微淋巴管生成有关,可在一定程度上预测肺癌的侵袭及转移。Purpose There is a certain correlation between parameters of CT perfusion imaging and pathological type and angiogenesis in lung cancer,in order to discuss the value of CT perfusion imaging parameters such as blood volume（BV）,blood flow（BF）,time to peak（TTP） and peak enhancement image（PEI） for prognosis,this study is designed to observe the relationship between the parameters of CT perfusion imaging and micro lymphovascular density（MLVD） in non-small cell lung cancer（NSCLC）. Materials and Methods 100 patients were enrolled in the study,all of them underwent CT perfusion imaging and 60 were diagnosed NSCLC by pathology,immunohistochemical staining was performed to determine the expressions of MLVD of the 60 NSCLC,and the correlation analyses were carried out to determine the relationship between CT perfusion imaging and MLVD. Results The expression of MLVD was the most in the peripheral tissue of cancer（25.16±1.28）,the next in the cancer tissue（16.38±3.58）,and the least in the normal lung tissue（7.56±4.38）,the difference was statistically significant（P〈0.05）. There was positive correlation between MLVD with BF and BV of the tumor（r=0.643 and 0.598,P〈0.01）. Conclusion Some parameters of CT perfusion imaging are correlated with MLVD,the invasion and metastasis in lung carcinoma can be predicted to some extent according to this correlation. Parameters of CT perfusion imaging such as BF and BV are correlated with MLVD in patients with NSCLC,thus can be used to predict the invasion and metastasis of lung cancer.

关 键 词：癌 非小细胞肺 体层摄影术 X线计算机 灌注成像 淋巴管生成 预后 病理学 外科 

分 类 号：R734.2[医药卫生—肿瘤] R730.42[医药卫生—临床医学]