脑梗死患者同型半胱氨酸水平及其相关因素的研究  

Study on the homocysteine level and related factors in patients with cerebral infarction

作　　者：王兴宁[1] 李慧[1] 白利芬[1] 米思蓉[1] 王碧延 雷光星[1] 

机构地区：[1]延安大学附属医院检验科,陕西延安716000

出　　处：《中国卫生检验杂志》2015年第20期3475-3477,共3页Chinese Journal of Health Laboratory Technology

基　　金：国家高技术研究发展计划(863计划)子课题(2011-AA02A111)

摘　　要：目的探讨脑梗死患者同型半胱氨酸(Hcy)水平及其相关因素的关系。方法收集延安大学附属医院2011年12月-2013年12月住院的脑梗死患者411例为脑梗死组,以同期正常体检者285例为对照组,分别测定其同型半胱氨酸、叶酸、维生素B12水平,并使用头颅CT或MRI检查脑梗死组患者梗死部位及梗死灶大小,按不同的组别进行分组,分别分析讨论各组间同型半胱氨酸水平的差异。结果脑梗死组Hcy明显高于正常对照组,男性高于女性,随着年龄的增长,Hcy水平逐渐增高;叶酸和维生素B12降低组Hcy水平均明显升高;Hcy水平与梗死部位、梗死面积无明显关系。结论 Hcy水平的升高与脑梗死的发生密切相关,但脑梗死发生之后,Hcy水平并不随着病情的严重程度而发生变化;高Hcy血症与体内叶酸及维生素B12水平低下有关,补充叶酸及维生素B12以降低Hcy可能是预防脑梗死的有效方法。Objective To probe the relationship between the homocysteine（ Hcy） levels and its related factors of the patients with cerebral infarction. Methods 411 cases who were hospitalized patients with cerebral infarction from December 2011 to December 2013 in the Affiliated Hospital of Yan＇an University were collected as a group,while 285 cases who performed the normal physical examination in the same period as a control group,then determine respectively the homocysteine,folic acid,vitamin B12 levels and use skull CT or MRI to examine the location and size of infarction in patients with cerebral infarction. Analyzed separately according to the different group to group,and the differences of the homocysteine levels in the groups were analyzed. Results The Hcy in cerebral infarction group was significantly higher than that of normal control group,and male was higher than female. Hcy level increased gradually with the increasing of the age,and male was higher than female; Hcy level of folic acid and vitamin B12 lower group were significantly increased. Hcy level has no obvious relation with the position and area of infarction. Conclusion The elevation of the Hcy level is closely correlated with the occurrence of cerebral infarction,but after cerebral infarction occurrence,Hcy level does not change with the severity of the illness. High Hcy hyperlipidemia is associated with folic acid and low vitamin B12 level,supplement folic acid and vitamin B12 to reduce Hcy may be an effective method to prevent cerebral infarction.

关 键 词：脑梗死 同型半胱氨酸 叶酸 维生素B12 

分 类 号：R743.33[医药卫生—神经病学与精神病学]