肉芽肿性血管炎致缺血性肠病1例  

Ischemic bowel disease associated with granulomatosis with polyangiitis: A case report

作　　者：吴静[1] 牛俊坤[1] 缪应雷[1] 

机构地区：[1]昆明医科大学第一附属医院消化内科云南省消化疾病研究所,云南省昆明市650032

出　　处：《世界华人消化杂志》2015年第29期4765-4770,共6页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;Nos.81160055;81260074;云南省科技厅昆明医学院联合专项基金资助项目;Nos.2011FB183;2007C0010R;云南省卫生厅卫生系统学科带头人培养计划基金资助项目;No.D-201215;云南省社会发展科技计划基金资助项目;No.2013CA021~~

摘　　要：肉芽肿性血管炎(既往称为韦格纳肉芽肿)是一种以坏死性肉芽肿性血管炎为病理特征的多系统受累的自身免疫性疾病,主要累及上、下呼吸道和肾脏,甚少出现胃肠道表现.病变累及小肠或结肠时出现肠缺血和继发性腹膜炎症状,如腹痛、发热、腹泻、血便,但缺乏特异性,容易误诊.本文报告肉芽肿性血管炎致缺血性肠病1例,旨在提高临床医生对该病罕见临床表现的认识,早期诊断、早期治疗以延长患者生存期.Granulomatosis with polyangiitis（GPA）is a chronic multisystemic disorder of unknown etiology that leads to necrotising granulomatous vasculitis,commonly involving the respiratory system and the kidneys.Gastrointestinal involvement is a rare manifestation of this disease.Although uncommon,GPA may involve the small bowel or colon and exhibit symptoms of intestinal ischemia and secondary peritonitis,including abdominal pain,fever,diarrhea and gastrointestinal bleeding which are nonspecific.Here we report a case of ischemic bowel disease associated with granulomatosis with polyangiitis to improve the awareness by clinicians.

关 键 词：肉芽肿性血管炎 韦格纳肉芽肿 缺血性肠病 

分 类 号：R593.9[医药卫生—内科学]