探讨结构脂肪乳剂对胃肠肿瘤患者静息能量代谢和脂质过氧化的影响  

Study on the structure of fat emulsion effect on resting energy metabolism and lipid peroxidation in patients with gastrointestinal cancer

作　　者：唐城[1] 曹超[1] 阮丽琴[1] 

机构地区：[1]南昌大学第一附属医院,江西南昌330000

出　　处：《临床医药实践》2015年第11期803-805,共3页Proceeding of Clinical Medicine

摘　　要：目的:研究结构脂肪乳剂(C6-24力文)对胃肠肿瘤患者静息能量代谢和脂质过氧化的影响。方法:选取2013年7月—2014年7月在我院接受治疗的胃肠道肿瘤患者82例,随机分为结构脂肪乳剂(STG)组和中长链脂肪乳剂(MCT/LCT)组,每组41例。患者在术后第2天至第6天分别采用STG和MCT/LCT构成的等氮、等热量肠外营养(PN)支持,共5 d。结果:接受手术后第6天,STG组胃肠肿瘤患者累计氮平衡值与MCT/LCT组胃肠肿瘤患者相比较低(P<0.05);STG组胃肠肿瘤患者在术后的第1天至第4天超敏C-反应蛋白(hs-CRP)水平与MCT/LCT组患者相比较低(P<0.05)。STG组胃肠肿瘤患者血清丙二醛(MDA)浓度低于MCT/LCT组患者,差异有统计学意义(P<0.05),STG组胃肠肿瘤患者谷胱甘肽过氧化物酶(GSH-Px)水平高于MCT/LCT组患者,差异有统计学意义(P<0.05)。结论:STG组胃肠肿瘤患者采用PN支持治疗所造成的机体代谢紊乱更小,胃肠肿瘤患者在减轻脂质过氧化损伤和维护能量代谢稳定方面,STG比MCT/LCT效果更好。Objective：To study the structure of fat emulsion（C6 - 24 Li Wen）effect on resting energy metabolism and lipid peroxidation in patients with gastrointestinal cancer. Methods：From 2013 July to 2014 July 82 patients with gastrointesti-nal tumor treated in hospital,which were randomly divided into structure of fat emulsion（STG）group and medium and long chain triglyceride emulsion（MCT/ LCT）group,two groups each of 41 patients. Patients in the postoperative 2 -6 days respec-tively by STG and MCT/ LCT etc. constituten,heat PN support,5 d. Results：after an operation group 6 d STG of gastrointestinal tumor patients accumulated nitrogen balance value and the MCT/ LCT group of gastrointestinal tumor patients compared to the lower（P 〈 0. 05）. The level of 4 d hypersensitive C - reactive protein（hs - CRP）and MCT/ LCT groups were compared with low STG group of gastrointestinal tumor patients first after operation（P 〈 0. 05）. Serum Malondialdehyde（MDA）in the pa-tients with gastrointestinal tumor concentration of STG group was lower than that of group MCT/ LCT patients of gastrointestinal tumor,statistically significant data difference（P 〈 0. 05）,STG group of gastrointestinal cancer patients and the level of gluta-thione peroxidase（GSH - Px）was higher than group MCT/ LCT patients of gastrointestinal tumor,statistically significant data difference（P 〈 0. 05）. Conclusion：STG group of gastrointestinal tumor patients using PN to support smaller metabolic disor-ders caused by the treatment of gastrointestinal tumor patients,in terms of reducing lipid peroxidation damage and maintain the stability of energy metabolism,STG better than MCT/ LCT.

关 键 词：结构脂肪乳剂 胃肠肿瘤 静息能量代谢 脂质过氧化 

分 类 号：R735[医药卫生—肿瘤]