输尿管癌根治性切除术与输尿管部分切除术的疗效比较  

Comparison of clinical efficacy between radical nephroureterectomy and partial ureterectomy

作　　者：高靖达 刘春雨[1] 王锐[1] 邢力永 孙二琳[2] 刘利维[1] 

机构地区：[1]天津医科大学第二医院泌尿外科,天津300211 [2]天津市泌尿外科研究所

出　　处：《临床泌尿外科杂志》2015年第11期1021-1024,共4页Journal of Clinical Urology

摘　　要：目的:比较输尿管癌根治性切除术与输尿管部分切除术治疗早期输尿管尿路上皮癌的临床疗效。方法:我院2005年1月~2014年6月收治早期输尿管尿路上皮癌(Ta^T2a期)患者79例,根据手术方式将79例分为输尿管癌根治性切除组50例和输尿管部分切除术组29例,比较两组患者术后膀胱无复发生存率、输尿管无复发生存率、无远处转移生存率和肿瘤特异性生存率,研究两组手术方式的临床疗效。结果:两组患者术后膀胱无复发生存率(P=0.718)、输尿管无复发生存率(P=0.818)、无远处转移生存率(P=0.533)和肿瘤特异性生存率(P=0.827)比较,差异均无统计学意义。低级别和高级别输尿管肿瘤患者膀胱无复发生存率、输尿管无复发生存率和肿瘤特异性生存率比较,差异均无统计学意义。结论:早期输尿管尿路上皮癌患者行输尿管癌根治性切除术与输尿管部分切除术疗效相似,输尿管部分切除术对于早期输尿管尿路上皮癌患者是一种可行、有效的手术方案。Objective： To compare the clinical efficacy between radical nephroureterectomy and partial ureterec- tomy in treatment of early ureteral transitional cell carcinoma. Method： A retrospective review of 79 patients with early ureteral transitional cell carcinoma （Ta-T2a） from January 2005 to June 2014 at our hospital was performed. According to surgical method, 79 patients were divided into radical nephroureterectomy group （50 cases） and partial ureterectomy group （29 cases）. We compared the bladder recurrence-free survival, the ureter recurrence-free survival, the distant metastasis-free survival and the cancer-specific survival between the two groups in order to study the clinical efficacy of the two groups. Result.. There was no statistically significant difference in the bladder recurrence-free survival （P= 0. 718）, the ureter recurrence-free survival （P= 0. 818）, the distant metastasis-free survival （P=0. 533） and the cancer-specific survival （P=0. 827） between the two groups. Also, the bladder recurrence-free survival, the ureter recurrence-free survival and the cancer-specific survival in both the low grade and the high grade ureteral carcinoma had no statistically significant difference. Conclusion： The efficacy between radical nephroureterectomy and partial ureterectomy in treating early ureteral transitiortal cell carcinoma is similar. Thus, partial ureterectomy is a feasible surgical procedure for patients with early ureter transitional cell carcinoma.

关 键 词：输尿管肿瘤 移行细胞癌 手术 预后 

分 类 号：R737.13[医药卫生—肿瘤]