饮茶习惯和老年认知功能损害的相关性研究  

The Association between Tea-drinking Habit and Cognitive Impairment in Elderly

作　　者：梁小妞 陈映东 丁玎[4] 罗剑锋[1,2,3] 赵倩华[4] 郭起浩[4] 周燕[4] 俞丽蓉[4] 郑琍 洪震[4] 

机构地区：[1]复旦大学公共卫生学院生物统计教研室,200032 [2]复旦大学公共卫生安全教育部重点实验室,200032 [3]复旦大学卫生部卫生技术评估重点实验室,200032 [4]复旦大学附属华山医院神经内科,200040

出　　处：《中国临床神经科学》2015年第5期531-536,共6页Chinese Journal of Clinical Neurosciences

基　　金：复旦大学自主科研项目(编号:20520133106)

摘　　要：目的调查研究社区50岁以上老年人群中饮茶习惯与痴呆和轻度认知功能障碍（MCI）的相关性。方法采用横断面调查,对≥50岁的社区居民进行全套神经系统体检、神经心理测试,根据国际统一的诊断标准诊断痴呆和MCI。采用问卷调查研究对象的饮茶习惯,包括开始饮茶的年龄,饮茶的量和种类等。采用Logistic回归模型分析饮茶各因素与痴呆和MCI的相关性。结果完成全部测试项目的 3 756名研究对象中,159名（4.2%）诊断为痴呆,696名（18.5%）诊断为MCI。单因素分析中,饮茶、每月饮茶量、饮用绿茶及每月饮用绿茶量4个因素在痴呆组、MCI组和认知正常组的组间差异均有统计学意义（P〈0.05）。经多因素分析校正多个变量后发现：饮茶是痴呆（OR=0.352,95%CI：0.197-0.629）和MCI（OR=0.740,95%CI：0.602-0.910）的保护因素;每月饮茶量多是痴呆（OR=0.847,95%CI：0.727-0.988）的保护因素;饮用绿茶是痴呆（OR=0.318,95%CI：0.171-0.591）和MCI（OR=0.738,95%CI：0.595-0.916）的保护因素;每月饮用绿茶量多是痴呆（OR=0.829,95%CI：0.709-0.971）的保护因素。结论老年人有规律饮茶,尤其是绿茶,可以预防认知功能损害的发生。Aim To investigate the correlation between tea-drinking and dementia as well as mild cognitive impairment（MCI） of elderly aged fifty or older in a community. Methods A cross-sectional study was used. Residents with 50 years or older were interviewed with neurological examination and neuropsychological tests. Diagnosis of dementia and MCI was made based on the international diagnosticcriteria. Through questionnaires, their tea-drinking habits, including the onset age, amount and types of drinking tea were investigated. Logistic regression was used to analyze the association between tea factors and dementia or MCI. Results For the 3756 cases, 159（4.2%） cases were diagnosed with dementia and 696（18.5%） cases were diagnosed with MCI. Among groups of dementia, MCI and cognition normal groups, drinking tea, total amount of drinking tea per month, drinking green tea and total amount of drinking green tea per month had significant difference（P〈0.05）. In the multivariate Logistic regression model adjusting multiple variables, drinking tea was protective factor of dementia（OR=0.352, 95%CI： 0.197-0.629） and MCI（OR=0.740, 95%CI： 0.602-0.910）, the more total amount of drinking tea was protective factor of dementia（OR=0.847, 95%CI： 0.727-0.988）, drinking green tea was protective factor of dementia（OR=0.318, 95%CI： 0.171-0.591） and MCI（OR=0.738, 95%CI： 0.595-0.916） and the more total amount of drinking green tea was protective factor of dementia（OR=0.829, 95%CI： 0.709-0.971）. Conclusion Drinking tea regularly, especially green tea, can prevent the occurrence of cognitive impairment for the elderly.

关 键 词：饮茶 轻度认知功能障碍 痴呆 老年 危险因素 横断面调查 

分 类 号：R749.1[医药卫生—神经病学与精神病学]