卡培他滨维持化学治疗对晚期胃癌和术后复发转移胃癌的效果观察  

Role of Capecitabine Maintenance Chemotherapy in Improving Tolerance and Prolonging Survival in the Treatment of Advanced Gastric Cancer and Recurrence and Metastasis of Gastric Cancer

作　　者：黄印强[1] 吴清艺[1] 朱英霞[1] 

机构地区：[1]福建省泉州市光前医院化疗科,泉州362321

出　　处：《中国医药导刊》2015年第10期1028-1029,1032,共3页Chinese Journal of Medicinal Guide

摘　　要：目的：探讨卡培他滨维持化学治疗（化疗）治疗晚期胃癌和术后复发转移胃癌的效果。方法：运用随机抽样的方法选取我院2013年1月-2014年9月收治的80例晚期胃癌和术后复发转移胃癌患者,依据治疗方法将这些患者分为研究组（n=40）和对照组（n=40）。给予对照组患者常规治疗,给予研究组患者常规治疗基础上的卡培他滨维持化疗治疗。结果：研究组患者治疗的总有效率60.0%（24/40）、85.0%（34/40）均显著高于对照组40.0%（16/40）、60.0%（24/40）（P〈0.05）,中位生存期显著长于对照组（P〈0.05）,1年、2年生存率均显著高于对照组（P〈0.05）。结论：卡培他滨维持化疗治疗晚期胃癌和术后复发转移胃癌能够有效提高患者耐受性、延长生存期。Objective： To investigate the effects of capecitabine maintenance chemotherapy in the treatment of advanced gastric cancer and recurrence and metastasis of gastric cancer.Methods：80 cases of advanced gastric cancer recurrence and metastasis of gastric cancer patients who were treated in our hospital from January 2013 to September 2014 were selected by random sampling method,they were divided into study group（n=40） and control group（n=40） according to the treatment methods.The control group were given conventional treatment,while the study group were given capecitabine maintenance chemotherapy on the basis of conventional treatment.Results：The total effective rate of the study group 60.0%（24/40）, 85.0%（34/40） was significantly higher than the control group 40.0%（16/40）, 60.0%（24/40）（P〈0.05）,the median survival time was significantly longer（P〈0.05）,the 1-year,2-year survival rate were significantly higher than the control group（P〈0.05）.Conclusion：Capecitabine maintenance chemotherapy can improve tolerance and prolong survival in the treatment of advanced gastric cancer and recurrence and metastasis of gastric cancer.

关 键 词：卡培他滨维持化疗 晚期胃癌 术后复发转移胃癌 耐受性 生存期 

分 类 号：R735.2[医药卫生—肿瘤]