化疗后序贯放疗与夹心治疗在广泛期小细胞肺癌中的应用比较  

Application Comparison of Sequential Radiotherapy after Chemotherapy and Sandwich Therapy in the Treatment of Extensive Stage Small Cell Lung Cancer

作　　者：张贵芳[1] 王莉莉[1] 曾琼[1] 

机构地区：[1]三峡大学第三临床医学院葛洲坝中心医院肿瘤科,宜昌443002

出　　处：《中国医药导刊》2015年第10期1055-1056,1065,共3页Chinese Journal of Medicinal Guide

摘　　要：目的：比较化学治疗（化疗）后序贯放射治疗（放疗）与夹心治疗在广泛期小细胞肺癌中的应用效果。方法：选取2010年4月-2013年5月我院收治的45例广泛期小细胞肺癌患者,依据随机数字表法将这些患者分为两组,即化疗后序贯放疗组（25例）和夹心治疗组（20例）。给予化疗后序贯放疗组患者化疗-放疗治疗,给予夹心治疗组患者化疗-放疗-化疗治疗。结果：两组患者治疗的总有效率之间的差异不显著（P〉0.05）;两组患者的中位生存时间之间的差异不显著（P〉0.05）,1年、2年生存率之间的差异也均不显著（P〉0.05）;两组患者的毒副反应发生率和胸内复发之间的差异均不显著（P〉0.05）。结论：化疗后序贯放疗与夹心治疗在广泛期小细胞肺癌中的应用效果相似。Objective： To compare the application effect of sequential radiotherapy after chemotherapy and sandwich therapy in the treatment of extensive stage small cell lung cancer.Methods：45 cases of lung cancer patients with extensive stage small cell in our hospital from Apil. 2010 to May 2013 were selected,these patients were divided into two groups according to the random number table,namely,sequential chemotherapy radiotherapy group（25 cases） and Sandwich treatment group（20 cases）.Sequential chemotherapy radiotherapy group were given chemotherapy- radiotherapy, while the Sandwich treatment group were given chemotherapy sandwich- Radiotherapy- Chemotherapy.Results：The difference of the efficiency between the two groups was not significant（P〉0.05）;The difference of median survival time was not significant（P〉0.05）,the difference of 1-year,2-year survival rates were also not significant（P〉0.05）;the differences of toxicity and the incidence of intrathoracic recurrence rate were not significant（P〈0.05）.Conclusion：The application effect of sequential radiotherapy after chemotherapy and sandwich therapy are similar in the treatment of extensive stage small cell lung cancer.

关 键 词：化疗后序贯放疗 夹心治疗 广泛期小细胞肺癌 应用 比较 

分 类 号：R734.2[医药卫生—肿瘤]