hTERC基因在筛查宫颈病变中的价值  

The value of hTERC gene in screening cervical lesions

作　　者：王莹[1] 肖琳[1] 孙佳星[1] 米贤军[1] 栾峰[1] 

机构地区：[1]南方医科大学附属中山市博爱医院妇科,广东中山528400

出　　处：《中国优生与遗传杂志》2015年第11期1-3,9,共4页Chinese Journal of Birth Health & Heredity

基　　金：国家科技部"十一五"重点支撑项目(项目编号:2008BAI57B01);广东省科技计划项目(项目编号:2012B031800023);中山市科技计划项目重大专项(项目编号:20113A004)

摘　　要：宫颈癌是引起女性死亡最常见的生殖道恶性肿瘤,作为目前唯一一种可以预防的恶性肿瘤,及时发现并干预癌前病变的进展和演变,可有效阻断宫颈癌的发生。宫颈癌三阶梯筛查已经在国内广泛应用,但有其不足之处。研究发现人类染色体端粒酶RNA基因(位于3q26.3)的异常扩增在宫颈癌的发生发展中起着重要的作用,h TERC基因也许可作为筛查及诊断宫颈病变新手段。Cervical cancer is the principal cause of mortality due to cancer in women worldwide. Because of the long process,it is very important for timely detection of precancerous lesions and effective intervention to block the occurrence of cervical cancer. The three-step screening,cytology-colposcopy-histology,is widespread used in China,which still have many limitations.It was demonstrated that amplification of the human telomerase RNA gene component（h TERC）gene in 3q26.3 3q26.3is key to cervical cancer progression,hence,h TERC gene may be a marker for screening and diagnosing cervical lesions.

关 键 词：宫颈病变 HTERC基因 荧光原位杂交技术 

分 类 号：R737.33[医药卫生—肿瘤]