扎托洛芬的合成  

Synthesis of Zaltoprofen

作　　者：周勇[1] 陈文华[1] 

机构地区：[1]常州工程职业技术学院制药与生物工程技术系,江苏常州213164

出　　处：《中国医药工业杂志》2015年第11期1167-1168,共2页Chinese Journal of Pharmaceuticals

摘　　要：2-(3-羧甲基-4-苯硫基苯基)丙酸与甲醇酯化生成2-(3-甲氧羰基甲基-4-苯硫基苯基)丙酸甲酯,然后与多聚磷酸环合,水解制得扎托洛芬,总收率89%,纯度99.3%。该工艺操作简便,收率高,易于工业化生产。Zaltoprofen was synthesized from 2-（3-carboxymethyl-4-phenylthiophenyl）propionic acid via esterification with methanol to give methyl 2-（3-methoxycarboxymethyl-4-phenylthiophenyl）propionate, which was subjected to cyclization with polyphosphoric acid, and hydrolysis with an overall yield of 89% and a purity of 99.3 %. This process was suitable for industrial production with simple operation and high yield.

关 键 词：扎托洛芬 非甾体抗炎药 合成 

分 类 号：R971.1[医药卫生—药品]