冬胃颗粒与良附丸治疗寒区寒凝血瘀型胃脘痛的临床对照研究  

A controlled clinical trial of Dongwei ganule and Liangfu wan in the treatment of epigastralgia caused by cold coagulation and blood stasis

作　　者：朱虹[1] 胡文平[1] 张仁诚[1] 于丽[1] 高秋[1] 高文艳[1] 刘杨[1] 李禹廷[1] 吴卓霖[1] 盛天骄[1] 刘俊丽[1] 

机构地区：[1]沈阳军区总医院中医科国家中西医结合消化病重点专科,辽宁沈阳110840

出　　处：《中国中西医结合消化杂志》2015年第10期696-699,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：军队"十二五"中医药专项重点课题基金(No:10ZYZ102)

摘　　要：[目的]观察比较冬胃颗粒与良附丸治疗寒凝血瘀型胃脘痛临床疗效及安全性。[方法]80例寒凝血瘀型胃脘痛患者随机分为试验组(40例),给予冬胃颗粒6g,2次/d,对照组(40例)给予良附丸6g,2次/d,均于两餐间服用,疗程为1周,观察各组第1、3、7天腹痛腹胀、泛酸、嗳气与纳差症状缓解改善情况,同时观察其安全性。[结果]2组患者均有一定疗效,但冬胃颗粒治疗后在第1、3天两个时间点,在腹痛症状疗效指标的评价均优于良附丸,差异有统计学意义(P<0.01),在第7天,2组腹痛症状指标相似(P>0.05),以有序logistic模型重复测量GEE分析方法,多点综合重复评价,冬胃颗粒对腹痛症状疗效指标总的评价优于良附丸,差异有统计学意义(P<0.01)。在第1、3、7天三个时间点,泛酸效指标的评价均优于良附丸,差异有统计学意义(P<0.01),虽然在第1、3、7天,在嗳气、纳差症状疗效指标显示冬胃颗粒略优于良附丸,但差异无统计学意义(P>0.05),2组患者均未见明显不良反应。[结论]冬胃颗粒与良附丸均可有效缓解寒凝血瘀型胃脘痛及相关症状,但前者可更快速缓解疼痛并有效控制泛酸症状,2者均无明显不良反应。[Objective]To observe and compare the clinical efficacy and safety of Dongwei granule and Liangfu wan in the treatment of epigastralgia with syndrome of cold coagulation and blood stasis.[Methods]Eighty patients of epigastralgia with syndrome of cold coagulation and blood stasis were randomly divided into test group（n=40）treated with Dongwei granule 6g bid,and control group（n=40）given with Liangfu-wan 6g bid,which were all taken between two meals for seven days as a course of treatment.The improvement of abdominal pain and distension,acid regurgitation,belching,symptoms of anorexia,and safety were observed on the first,third and seventh day.[Results]Both groups had a certain effect,however,on the first day and on the third day,the evaluation of curative effect（ECE）for abdominal pain of Dongwei granule was superior to that of Liangfu wan,and the difference was statistically significant（P〈0.01）.On the seventh day,the ECE of the both groups in abdominal pain was similar（P〉0.05）.However,analysed by the ordered logistic model duplicate measurement GEE analysis method and multi point comprehensive evaluation,the ECE of Dongwei granule in abdominal pain was better than that of Liangfu-wan group,the difference was statistically significant（P〈0.01）.On three time points the ECE of Dongweigranule in acid regurgitation gained an advantage over that of Liangfu wan,the difference was statistically significant（P〈0.01）.Although on three time points the ECE of Dongwei granule in belching and anorexia were slightly better than that of Liangfu-wan,but there was no statistical significance（P〉0.05）,and no obvious side-effects were found.[Conclusion]Dongwei granule and Liangfu wan can effectively alleviate epigastralgia caused by cold coagulation and blood stasis and associated symptoms,but the former could relieve the pain more rapidly and effectively control the symptoms of acid.No side-effects were found in both of them.

关 键 词：寒凝血瘀 胃脘痛 冬胃颗粒 良附丸 

分 类 号：R573[医药卫生—消化系统]