Mir-125a与相关疾病关系的研究进展  

Advances in miR-125a and its relative diseases

作　　者：范忠义[1] 焦顺昌[1] 

机构地区：[1]解放军总医院肿瘤内一科,北京100853

出　　处：《解放军医学院学报》2015年第11期1152-1155,共4页Academic Journal of Chinese PLA Medical School

基　　金：国家自然科学基金项目(81472589;31100604)~~

摘　　要：微小RNA（microRNA,mi RNA）是一类长度为19~25 nt的单链非编码RNA,研究发现其具有多种生物学功能,调控大多数的细胞生物学进程。随着研究的深入,miRNA的功能及其调控网络也得到了进一步的认识。miR-125a是最近研究较多的mi RNA,其主要作为抑癌基因发挥抑制肿瘤生长、转移的作用。本文简要综述了miR-125a与相关疾病的研究进展,以期全面了解miR-125a的生物学功能及作用靶点,为miR-125a的临床应用提供理论依据。micro RNA（mi RNAs） is short non-coding RNA molecules with length of 19~25 nt. Previous studies find that it has a variety of biological functions, and it regulates most cell process. With further research on mi RNAs, more and more functions have been discovered and characterized. mi R-125 a is a hot point of mi RNAs researches, and it works as a tumor suppressor to inhibit growth and metastasis of tumor cell. This review focuses on the advances in mi R-125 a functions and related diseases, which will helP〈0us fully understand the biological function and target of mi R-125 a, in order to provide theoretical basis for the clinical application of mi R-125 a.

关 键 词：微小RNA miR-125a 分子生物学 肿瘤 

分 类 号：Q291[生物学—细胞生物学] R73[医药卫生—肿瘤]