以肿瘤相关巨噬细胞为靶点的抗肿瘤研究进展  

Progress of tumor-associated macrophages as an therapeutic target against tumors

作　　者：朱卫平[1] 赵一鸣[1] 王鲁[1] 

机构地区：[1]复旦大学附属肿瘤医院肝脏外科,上海200032

出　　处：《国际外科学杂志》2015年第10期697-700,共4页International Journal of Surgery

基　　金：国家自然科学基金资助项目（No.81372314;No.81272393）

摘　　要：肿瘤相关巨噬细胞存在于肿瘤微环境中,在抗肿瘤治疗过程中,能发生免疫重塑,影响肿瘤进展.越来越多的证据表明,临床上许多抗肿瘤措施能够通过调控肿瘤微环境中巨噬细胞募集、极化及其相关的促肿瘤行为发挥独特而有效的抗肿瘤作用.日前,肿瘤微环境免疫重塑成为了抗肿瘤治疗研究的热点.本文就以肿瘤微环境中肿瘤相关巨噬细胞为靶点的抗肿瘤研究相关进展作一综述.Tumor-associated macrophages （TAMs） exist in the tumor microenvironment,and can be affected by various anticancer treatments and further affect tumor progression.Increasing evidence suggests that many of the clinical antitumor measures can play a unique and effective antitumor effect by regulating the recruitment,polarization and related pro-tumor behavior of macrophages in the tumor microenvironment.Now,tumor microenvironment immune remodeling has become a hot spot in the research of anti-tumor therapy.This paper reviews the related research progress on antitumor effects of TAMs as an therapeutic target.

关 键 词：巨噬细胞 肿瘤 肿瘤微环境 

分 类 号：R735.2[医药卫生—肿瘤]