结晶样脉络膜视网膜变性患者血液成分的异常变化特点  

Abnormal blood profiles in patients with Bietti crystalline dystrophy:a retrospective analysis

作　　者：崔卉[1] 闫博婧[1] 吴志中[1] 李根林[1] 

机构地区：[1]首都医科大学附属北京同仁医院 北京同仁眼科中心 北京市眼科学与视觉科学重点实验室,100730

出　　处：《中华眼科医学杂志（电子版）》2015年第5期9-13,共5页Chinese Journal of Ophthalmologic Medicine(Electronic Edition)

基　　金：国家自然科学基金资助(编号:81271046)

摘　　要：目的了解结晶样视网膜色素变性(BCD)患者体内各种血液成分的变化情况,为探寻其发病机理和防治方法提供参考。方法收集2014年3月至2015年5月在首都医科大学附属北京同仁医院眼科中心就诊的48例(96只眼)经临床确诊为BCD患者和体检中心体检的150例(300只眼)正常人的临床资料,进行回顾性序列病例研究。将48例(96只眼)确诊为BCD的患者作为BCD组,将150例(300只眼)正常人作为对照组,按盲法由专业技术人员完成血液样本的血常规检查。BCD组和对照组患者红细胞(RBC)、白细胞(WBC)及血小板(PLT)的相关参数变化情况以均数±标准差(x珋±s)的形式表示,并采用独立样本t检验的方法进行组间比较。结果平均红细胞体积(MCV)、平均血红蛋白量(MCH)、平均血红蛋白浓度(MCHC)及红细胞体积分布宽度(RDW)等四项指标,BCD组患者分别为(87.43±7.09)f L,(29.39±3.20)pg,(335.27±15.72)g/L,(13.45±1.99)f L;对照组分别为(90.37±3.08)f L,(30.59±2.56)pg,(340.51±4.52)g/L,(13.07±0.54)f L。两组比较,差异有统计学意义(t=4.03,2.66,3.65,-2.12;P<0.05)。RBC计数、血红蛋白(HGB)量及红细胞压积(HCT)等三项指标,BCD组患者分别为(4.75±0.52)×1012/L,(139.33±20.37)g/L,(0.42±0.05);对照组分别为(4.65±0.36)×1012/L,(152.31±15.98)g/L,(0.42±0.03)。两组比较,差异无统计学意义(t=-1.45,1.54,0.8;P>0.05)。WBC计数、淋巴细胞(LYM)计数、单核细胞(MON)计数、中性粒细胞(NEU)计数、LYM比率、NEU比率、及嗜碱性细胞(BAS)比率等七项指标,BCD组患者分别为(5.57±1.34)×109/L,(1.87±0.48)×109/L,(0.35±0.10)×109/L,(3.22±1.11)×109/L,(34.50±8.23)%,(54.76±9.00)%,(0.36±0.30)%;对照组分别为(6.67±1.30)×109/L,(2.05±0.46)×109/L,(0.47±0.12)×109/L,(3.98±0.94)×109/L,(30.97±4.63)%,(59.55±5.29)%,(0.52±0.20)%。两组患者比较,差异有统计学意义(t=5.05,2.41,6.08,4.65,3.72,2.63,4.16;P<0.05)。嗜酸性细胞(EOS)计数、BAS计数、MON比率及EOS比率等�Objective To characterize abnormal changes in blood variables in patients with Bietti crystalline dystrophy（ BCD）. Methods Medical records of 48 BCDpatientswho visited the Department of Ophthalmology,Beijing Tongren Hospital between March 14,2014 and May,2015 and 150 control subjects who underwent annual physical examinations were obtained. Data on mean corpuscular volume（ MCV）,mean cell hemoglobin（ MCH）,mean cell hemoglobin concentration（ MCHC） and red cell distribution width（ RDW）,red blood cell（ RBC） count,white blood cell（ WBC） count,and platelet count（ PC） were analyzed by independent sample t test. Results MCV,MCH,MCHC and RDW were87. 43 ± 7. 09 fl,29. 39 ± 3. 20 pg,335. 27 ± 15. 72 g / L,and 13. 45 ± 1. 99 fL,respectively,in BCD patients and were 90. 37 ± 3. 08 fL,30. 59 ±2. 56 pg,340. 51 ± 4. 52 g / L and 13. 07 ± 0. 54 fL,respectively,in control subjects; differences in all these variables were significant between the two groups（ P 0. 05）. RBC,HGB,HCT were 4. 75 ± 0. 52 × 1012/ L,139. 33 ± 20. 37 g / L and 0. 42 ± 0. 05,respectively,in BCD patients and 4. 65 ± 0. 36 × 1012 / L,152. 31 ±15. 98 g / L and 0. 42 ± 0. 03,respectively,in control subjects; there were no significant differences in these variables between the two groups（ P 0. 05）. WBC,lymphocyte count,monocyte count,neutrophil ratio,lymphocyte ration,basophil ratio,andneutrophil countwere 5. 57 ± 1. 34 × 109/ L,1. 87 ± 0. 48） 109/ L,0. 35± 0. 10 × 109/ L,3. 22 ± 1. 11 × 109/ L,34. 50 ± 8. 23%,54. 76 ± 9. 00%,and 0. 36 ± 0. 3%,respectively,in BCD patients and were6. 67 ± 1. 30 × 109 / L,2. 05 ± 0. 46 × 109 / L,0. 47 ± 0. 12 × 109 / L,3. 98 ± 0. 94 ×109 / L,30. 97 ± 4. 63%,59. 55 ± 5. 29%,and 0. 52 ± 0. 20%,respectively,in control subjects; all these parameters were significantly different between the two groups（ P 0. 05）. Conclusion There are significant alterations in the blood chemistry in BCD patients. Our findings suggest blood profiling may have significant imp

关 键 词：结晶样视网膜色素变性 红细胞 白细胞 血小板 血常规检测 

分 类 号：R774.1[医药卫生—眼科]