循环肿瘤干细胞与原发性乳腺癌患者生存时间的相关性  

Correlation of circulating cancer stem cells and survival in patients with primary breast cancer

作　　者：李京烨 马德亮[1] 张佃富[1] 苏庆光[1] 

机构地区：[1]山东省临沂市沂水中心医院肿瘤科,临沂276400

出　　处：《中国肿瘤临床与康复》2015年第11期1281-1283,共3页Chinese Journal of Clinical Oncology and Rehabilitation

摘　　要：目的探讨循环肿瘤干细胞与原发性乳腺癌患者生存时间的相关性。方法对50例乳腺癌患者的外周血进行免疫组化检测,对患者进行随访,分析两者之间的关系。结果 50例患者中,CK19+/CD44+/CD24-/LOW阳性36例,阴性14例。乳腺癌组织上皮细胞的CK19+/CD44+/CD24-/LOW表达率明显高于癌旁组织,差异有统计学意义(P<0.05)。50例乳腺癌外周血标本中,Cerb B-2高表达患者癌组织中CK19+/CD44+/CD24-/LOW阳性表达率为85.2%(23/27),C-erb B-2低表达患者癌组织中CK19+/CD44+/CD24-/LOW阳性表达率为39.1%(9/23),且C-erb B-2表达强度随CK19+/CD44+/CD24-/LOW阳性率增加而增高,两组差异有统计学意义(P<0.05)。随CK19+/CD44+/CD24-/LOW表达的增高,患者发生远处转移及死亡率增高。结论动态监测循环肿瘤干细胞变化,有利于及时了解乳腺癌患者病情及治疗效果。Objective To explore the correlation of circulating cancer stem cells（ CSC） and survival in patients with primary breast cancer. Methods Totally 50 patients with breast cancer received the immune-histochemistry tests in peripheral blood. The patients were followed up. Results There were 32 positive staining cases in CK19＋/ CD44＋/ CD24-/ LOWand 18 negative cases. The incidence rate of CK19＋/CD44＋/ CD24-/ LOWof epithelial cell for breast cancer tissue was significantly higher than that of adjacent mammary gland tissue（ P 0. 05）. With the higher expression of CK19＋/ CD44＋/ CD24-/ LOW,the rate of distant metastasis and death rate were also increased. Based on Log-rank examinations,the survival curves for CK19＋/ CD44＋/ CD24-/ LOWwere compared. The highest the scores were,the lowest the survival rate was（ 2= 7. 650,P = 0. 025）. Conclusion To dynamically monitor the changes of circulating CSCs is beneficial to timely understand the state of illness and treatment effect.

关 键 词：乳腺肿瘤 肿瘤干细胞 生存时间 

分 类 号：R737.9[医药卫生—肿瘤]