Vogt—Koyanagi—Harada综合征恢复期患者视网膜血管血氧饱和度与血管直径测量  

The oxygen saturation and retinal blood vessel diameter in patients with convalescence Vogt-Koyanagi-Harada syndrome

作　　者：乐毅 张晓敏[1] 王梅艳 陈曦腾 杨锦 李筱荣[1] 

机构地区：[1]天津医科大学眼科医院、天津医科大学眼科研究所、天津医科大学眼视光学院,300384

出　　处：《中华眼底病杂志》2015年第6期545-548,共4页Chinese Journal of Ocular Fundus Diseases

基　　金：国家自然科学基金（81371005、81428012）;天津市自然科学基金（I5JCZDJC35600）

摘　　要：目的测量分析Vogt—Koyanagi—Harada（VKH）综合征恢复期患者视网膜血管血氧饱和度和血管直径。方法横断面研究。临床确诊为VKH综合征恢复期的14例患者28只眼（VKH组）及正常健康者10名20只眼（对照组）纳入研究。采用无创视网膜血氧饱和度分析仪对两组受检者视网膜动静脉的血氧饱和度和血管直径进行测量分析。受检者充分散瞳后取坐位，在暗室内采用570、600nm波长过滤器采集图像并将其融合后，用不同颜色标识视网膜血管血红蛋白氧饱和度。每位受检者均重复检查2～3次，取平均值。所有图像采集均由同一位技术员完成。每只眼仅选择一张最高质量的图像，通过仪器配套软件测量分析距离视盘1．5～3．0个视盘直径的视网膜动静脉血氧饱和度及血管直径。所有图像分析、数据采集均由另一技术员完成。结果VKH组、对照组受检者视网膜静脉血氧饱和度分别为（54．34±8．05）％、（60．07±7．91）％；VKH组患者视网膜静脉血氧饱和度较对照组受检者明显下降，差异有统计学意义（t=2．443，P=0．017）。VKH组、对照组受检者视网膜动脉直径分别为（102．8±18．1）、（112．9±19．8）μm；VKH组患者视网膜动脉直径较对照组受检者明显偏小，差异有统计学意义（t=2．406，P=0．018）。两组受检者视网膜静脉直径、视网膜动脉血氧饱和度及血氧饱和度动静脉差比较，差异均无统计学意义（t=0．014、1．353、-0．631，P=0．989、0．179、0．536）。结论与正常健康者比较，VKH综合征恢复期患者视网膜动脉直径明显变小，视网膜静脉血氧饱和度明显下降；视网膜静脉直径、视网膜动脉血氧饱和度及血氧饱和度动静脉差无明显变化。Objective To measure and analyze the oxygen saturation and retinal blood vessel diameter in the eyes of patients with convalescence Vogt-Koyanagi-Harada （VKH） syndrome. Methods In this cross-sectional study, 28 eyes of 14 patients with convalescence VKH syndrome （VKH group） and 20 eyes of 10 healthy subjects （control group） were enrolled. The oxygen saturation and retinal blood vessel diameter were detected by spectrophotometric oximetry unit. Retinal images were collected using filters with wavelengths of 570 nm and 600 nm in the darkroom by the same technologist and then the fused image was obtained. The oxygen saturation of retinal vessels was marked in different colors. The measurement was repeated 2 - 3 times for each patient, then take an average. A top-quality image in each eye was selected to detect the oxygen saturation and diameter of retinal vessel which located in 1.5 - 3.0 disc diameter from the optic disc. Image analysis and data acquisition were completed by another technologist. Results Retinal venous oxygen saturation was （54.34±8.05）% in the VKH group and （60.07± 7.91）% in the control group. The former was lower than the latter, the difference was significant （t = 2. 443, P= 0. 017）. The mean diameter of retinal arteries was （102.8±18.1） 9m in the VKH group and （112.9±19.8） μm in the control group. The former was smaller than the latter, the difference was significant （t= 2. 406, P= 0. 018）. There was no significant difference of the mean diameter of retinal veins, oxygen saturation of retinal arteries and the arterial-venous difference between two groups （t = - 0. 330, 0. 804, - 0. 631 ; P = 0. 743, 0. 403, 0. 536）. Conclusions Retinal venous oxygen saturation and the mean diameter of retinal arteries are significantly decreased in patients with VKH syndrome. There is no significant difference ofdiameter of retinal veins, oxygen saturation of retinal arteries and the arterial venous difference between VKH syndrome patients and healthy subjects.

关 键 词：葡萄膜脑膜脑炎综合征/并发症 血氧测定法 视网膜血管/病理生理学 

分 类 号：R774.1[医药卫生—眼科]