223例非小细胞肺癌骨转移发生骨相关事件的临床因素与预后  

Clinical factors and prognostic significance of skeletal related events in bone metastasis of non small cell lung cancer in 223 cases

作　　者：王帅[1] 李钱[1] 卿毅[1] 仲召阳[1] 单锦露[1] 关伟[1] 杨雪琴[1] 王阁[1] 杨镇洲[1] 王东[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所肿瘤中心,重庆400042

出　　处：《重庆医学》2015年第32期4504-4506,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(81171904);第三军医大学重大临床研究基金(2015001)

摘　　要：目的研究非小细胞肺癌（NSCLC）骨转移发生骨相关事件（SREs）的风险因素及其对患者预后的影响。方法回顾性研究2010-2012年该院223例NSCLC骨转移患者的临床特征,用单因素分析和多因素分析对SREs的预测因素分析。结果223例NSCLC骨转移患者中,发生SREs患者为119例（53.4%）。单因素分析显示女性、无吸烟史、腺癌、单发骨转移病灶患者发生SREs风险低于男性、吸烟史、非腺癌、多发骨转移病灶患者,差异有统计学意义（P〈0.05）,其余各项差异无统计学意义（P〉0.05）。多因素分析显示多发骨转移是发生SREs的独立风险因素。NSCLC骨转移患者的中位生存时间为15.3个月,生存分析显示NSCLC骨转移患者发生SREs对预后无显著影响（P〉0.05）。结论 NSCLC骨转移患者中,女性、腺癌、不吸烟史、单发骨转移病灶患者发生SREs风险更低,多发骨转移是发生SREs的独立风险因素,应注意监测和预防。Objective To explore the risk factors of skeletal related events（SREs）in non small cell lung cancer with bone metastases and its effect on the prognosis.Methods Totally 223 cases of NSCLC patients with bone metastasis were retrospective studied from January 2010 to December 2012 in our hospital.The clinical features,predictive factors for SREs were analysed by single factor and multifactor analysis.Results Among 223 cases of NSCLC patients with bone metastasis,119 cases occured with SREs（53.4%）.Univariate analysis showed that the occurrence of SREs in female,no smoker,adenocarcinoma,solitary bone metastasis lesions were less than the male,smoker non-adenocarcinoma,and multiple bone metastases（P〈0.05）,but the rost without statistically significant（P〈0.05）.The multivariate analysis revealed only multiple bone metastases was an independent risk factor for SREs.The median survival time of the NSCLC patients with bone metastasis was 15.3 months.Moreover,survival analysis showed that SREs had no statistical significance on the prognosis of bone metastasis in NSCLC patients（P〈0.05）.ConclusionThe female,adenocarcinoma,smoking history,solitary bone metastasis lesions occurred in patients with lower risk SREs.Multiple bone metastasis is an independent risk factor for SREs,attention should be paid to monitoring and prevention.

关 键 词：癌 非小细胞肺 骨转移 骨相关事件 

分 类 号：R734.2[医药卫生—肿瘤]