幽门螺杆菌感染与胰腺癌相关性的累积Meta分析  

A cumulative Meta analysis of association between H.Pylori infection and pancreatic cancer

作　　者：邓勇[1] 曾维琼[1] 詹柱 刘智力[1] 

机构地区：[1]重庆医科大学附属第二医院感染科,400010

出　　处：《重庆医学》2015年第32期4549-4552,共4页Chongqing medicine

摘　　要：目的对评估幽门螺杆菌感染与胰腺癌相关性的观察性研究进行Meta分析,旨在为幽门螺杆菌感染诱发胰腺癌的风险做出预测。方法检索Medline、EMBASE、Cochrane、PubMed、维普数据库,比较胰腺癌患者与健康对照者幽门螺杆菌感染率的观察性研究进行Meta分析。采用ELISA法检测血清幽门螺杆菌IgG水平,采用随机效应模型（D-L法）计算合并调整后的比值比（AOR）及95%CI。结果共6项研究,包括2 335例患者,符合本研究的筛选标准。累积Meta分析结果显示幽门螺杆菌感染与胰腺癌的发展存在显著相关性（AOR=1.38,95%CI：1.08-1.75,P=0.009）。其中3项研究结果表明血清幽门螺杆菌CagA抗体阳性与胰腺癌无显著相关性（AOR=1.14,95%CI：0.66-1.97,P=0.639）。结论幽门螺杆菌感染与胰腺癌之间存在显著相关性,但还需进一步验证。Objective To obtain a reliable estimate of the risk of H.pylori infection in causing pancreatic cancer,by performing a Meta-analysis of the existing observational studies evaluating the association.Methods Observational studies comparing the prevalence of H.pylori infection in patients with pancreatic cancer and healthy controls were identified through systematic search in the Medline,EMBASE,the Cochrane,PubMed,VIP database.H.pylori infection was confirmed by serological testing using an antigen-specific enzyme-linked immunosorbent assay.Pooled adjusted odds ratios（AOR）and associated 95% confidence intervals（CI）were obtained by using a Dersimonian and Laird random-effects model.Results Six studies involving a total of 2 335 patients met our eligibility criteria.A significant association between H.pylori seropositivity and development of pancreatic cancer（AOR=1.38,95%CI：1.08-1.75;P=0.009）was seen.No significant association had been seen on pooled analysis of the three studies assessing the relationship between CagA positivity and pancreatic cancer（AOR=1.14,95%CI：0.66-1.97,P=0.639）.Conclusion The data suggests an association between infection with H.pylori and the development of pancreatic cancer.Further research is needed to confirm our findings.

关 键 词：胰腺肿瘤 幽门螺杆菌 相关性 累积Meta分析 

分 类 号：R735.9[医药卫生—肿瘤]