紫杉醇脂质纳米粒子对KB细胞的作用  

Experimental study of the effect of paclitaxel nanoparticle on KB cells

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作  者:王宗站[1] 周宓[1] 杨金霞[1] 邢晓波[1] 田莹莹[1] 许玉杰[2] 

机构地区:[1]青岛市肿瘤医院放疗一科,山东青岛266042 [2]苏州大学放射医学与防护学院,江苏苏州215123

出  处:《现代肿瘤医学》2015年第23期3394-3397,共4页Journal of Modern Oncology

摘  要:目的:研究紫杉醇脂质纳米粒子(TAX-NLC)对KB细胞的作用。方法:激光共聚焦显微镜观察TAX-NLC作用于KB细胞对F-肌动蛋白(F-actin)的影响,并观察TAX-NLC作用于KB细胞诱导细胞凋亡情况,光镜观察TAX-NLC作用于KB细胞形态学的变化。结果:TAX-NLC使KB细胞F-actin聚集成团块状、点状,使微丝的功能受到抑制,TAX-NLC作用KB细胞诱导细胞凋亡,TAX-NLC作用KB细胞可产生大量多核细胞。结论:TAX-NLC破坏微丝功能,诱导凋亡及多核细胞,导致肿瘤细胞死亡。Objective: To study the action of paclitaxel nanoparticle( TAX-NLC) on KB cells. Methods: F-actin and apoptosis of KB cells after being exposed to TAX-NLC were observed by laser confocal microscopy. Cytomorphology of KB cells after being exposed to TAX-NLC was observed by light microscope. Results: After KB cells were exposed to TAX-NLC,F-actin of KB cells was gathered into a mass,punctate,the microfilament function was inhibited. The apoptosis of KB cells were induced by TAX-NLC. Many multinucleated cells of KB cells were induced by TAX-NLC. Conclusion: TAX-NLC destroyed microfilament function,induced apoptosis and multinucleated cells,finally tumor cells were killed.

关 键 词:紫杉醇脂质纳米粒子 紫杉醇 凋亡 多核细胞 

分 类 号:R730.53[医药卫生—肿瘤]

 

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