手术、放疗和光动力治疗分别联合小剂量化疗治疗早期声门型喉癌的疗效对比  

Effect of operation,radiotherapy and photodynamic therapy combined with low-dose chemotherapy in the treatment of early glottic carcinoma

作　　者：汤晨[1] 王成师[2] 刘收厚[1] 郁汉旭 

机构地区：[1]南京医科大学附属淮安第一医院耳鼻喉科,江苏淮安223300 [2]淮安市涟水县人民医院放疗科,江苏淮安223400

出　　处：《现代肿瘤医学》2015年第24期3580-3582,共3页Journal of Modern Oncology

基　　金：江苏省淮安市科技支撑计划(编号:2012018)

摘　　要：目的:比较手术、放疗和光动力治疗分别联合小剂量化疗治疗早期声门型喉癌的临床疗效。方法:回顾性分析本院收治的122例早期声门型喉癌患者的临床资料,按照治疗方法分为手术组(83例)、放疗组(20例)和光动力组(19例),均联合小剂量化疗。观察三组的3、5年总生存率、2年无瘤生存率和2年局部控制率,并进行比较。结果:8例患者失访,定为死亡或复发。三组患者3、5年总生存率、2年无瘤生存率和2年局部控制率经比较差异均无统计学意义(均P>0.05)。3组中一共有6例患者死于喉癌,1例患者死于第二原发恶性肿瘤,1例死于其他疾病。手术组13例出现并发症,放疗组7例出现并发症,光动力组2例出现并发症。入组患者中一共有27例出现复发转移,其中4例为颈部淋巴结转移,23例为原发灶复发。手术组、放疗组和光动力组分别有15例、3例和5例出现复发,三组复发率比较差异无统计学意义(P>0.05)。结论:手术、放疗和光动力治疗联合小剂量化疗治疗早期声门型喉癌可获得相似的临床疗效。Objective：To explore the curative effect of operation, radiotherapy and photodynamic therapy in combi- nation with small dose of chemotherapy in the treatment of early glottic cancer. Methods ： A retrospective analysis was performed on clinical data of 122 patients with early glottic cancer,and were divided into operation group（83 cases）, radiotherapy group（20 cases）, photodynamic therapy group （19 cases） according to treatment methods, were given joint of small dose chemotherapy. 3,5 years survival rate and 2 years tumor free survival rate and local control rate at 2 years of the three groups were observed and compared. Results ： Eight patients were lost to follow up, destined for death or recurrence. In 3 groups total of 6 patients died of laryngeal carcinoma, 1 patient died in second primary malig- nant tumor, 1 patient died of other diseases. Three patients of the 3 groups, the 5 years survival rate and 2 years tumor free survival rate and local control rate after 2 years were not significantly different （ P 〉 0.05 ）. Complications oc- curred in 13 cases in operation group, 2 cases occurred complications of photodynamic therapy group, radiotherapy group 7 cases with complications. A total of 27 cases developed recurrence and metastasis,including 4 cases of cervi- cal lymph node metastasis, 23 cases of recurrence in primary lesion. Photodynamic therapy group and radiotherapy group, operation group were 5 cases ,3 cases, 15 cases relapsed. Conclusion：It have similar chnical efficacy of surger- y, radiotherapy and photodynamic therapy combined with low - dose chemotherapy in the treatment of early glottic car- cinoma.

关 键 词：早期声门型喉癌 手术 放疗 光动力治疗 小剂量化疗 

分 类 号：R739.65[医药卫生—肿瘤]