局部晚期喉癌 3DCRT 与 IMRT 放疗计划的剂量学对比  

Dosimetric comparison with conventional radiation therapy and intensity modulated radiation therapy for locally advanced laryngeal carcinoma

作　　者：孙迪[1] 云惟康[1] 葛晓峰[1] 陈林[1] 胡洪涛[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨150081

出　　处：《实用肿瘤学杂志》2015年第5期420-423,共4页Practical Oncology Journal

基　　金：哈尔滨市科技创新人才研究专项资金项目（2009RFQXS015）

摘　　要：目的 利用ECLIPSE计划系统对局部晚期喉癌适形放疗（3DCRT）和逆向调强适形放疗（ IMRT）计划作剂量学比较,评估不同照射方法的优缺点. 方法 选择6例病理证实的局部晚期喉癌患者,用ECLIPSE对每例患者分别作出3DCRT和IMRT计划. 根据靶区V95%、D5%、D95%、靶区最大值、最小值及平均值和正常组织受量D50、D33、D5、Dmax和Dmean来比较这两种计划剂量学的差异. 结果 两种不同计划中的靶区分布中,GTV和GTVnd差别不大,但对于亚临床区CTV和某些正常组织有统计学差异. 结论 对局部晚期喉癌原发灶及阳性淋巴结,3DCRT和IMRT计划均有较好覆盖. 但在亚临床病灶方面,IMRT比3DCRT包含靶区更好一些,且IMRT减少了腮腺正常组织的照射剂量.Obejctive To compare the differences between conventional radiation therapy （3DCRT） and intensity modulated radiation therapy（ IMRT） for locally advanced laryngeal carcinoma patients by ECLIPSE treat -ment planning system.Methods Six locally advanced laryngeal carcinoma patients ′treatment plans were de-signed as IMRT and 3DCRT according to ECLIPSE treatment planning system ,respectively.The following values were measured,such as V95%、D5%、D95%、Dmin and D mean of the target volume,and the D50,D33,D5, Dmax and Dmean of normal tissues.Results The dose coverage rate of GTV and GTVnd in the IMRT plan was compared to ECLIPSE treatment planning system with no statistical differences.However, there were obvious difference in CTV and some normal tissues.Conclusion Both IMRT and 3DCRT have good coverage to primary tumor and metastatic lymph nodes.IMRT can spare the parotid from high dose irradiation.

关 键 词：局部晚期喉癌 适形放疗 逆向调强适形放疗 剂量学对比 

分 类 号：R73[医药卫生—肿瘤]