难治性抑郁症患者认知功能对照研究  

A control study of cognitive functions in patients with treat- ment-resistant depression

作　　者：马小燕[1] 季卫东[2] 

机构地区：[1]上海市长宁区精神卫生中心,中国·上海200335 [2]上海交通大学精神神经科学和系统代谢组学研究所,中国·上海200335

出　　处：《临床心身疾病杂志》2015年第6期90-91,153,共3页Journal of Clinical Psychosomatic Diseases

基　　金：“十二五”国家科技支撑计划项目（编号2012BA101804）;上海市长宁区卫生局特色专科建设项目（编号2012206001）;上海市长宁区卫生局特色专病建设项目（编号2011210416）

摘　　要：目的比较难治性抑郁症与非难治性抑郁症患者的认知功能，为临床诊治提供依据。方法对106例抑郁症患者采用汉密顿抑郁量表评定抑郁程度，威斯康星卡片分类测验、连线测试评定认知功能。随访1a末，将22例难治性抑郁症患者设为难治组，抽取38例非难治抑郁症患者设为非难治组。比较两组入组时的认知功能。结果难治组威斯康星卡片分类测验的完成分类数显著低于非难治组（P〈0．05），连线测试A的完成时间、抬笔时间和连线测试B的完成时间均显著长于非难治组（P〈0．05或0．01），其余测试项目比较差异无显著性（P〉0．05）。结论难治性抑郁症患者认知功能受损程度明显高于非难治性抑郁症患者。Objective To compare cognitive functions between patients with treatment-resistant （TR） and non-TR depression in order to provide basis for clinical diagnosis and treatment. Methods Depressive de- grees were assessed with the Hamilton Depression Scale （HAMD） and cognitive functions with the Wis- consin Cart Sorting Test （WCST） and Trail Marking Test （TMT） in 106 depression patients. At the end of 1 year follow-up, 22 TR depression patients were assigned to TR group and 38 non-TR ones to non-TR group. Cognitive functions were compared between two groups at enrolment. Results Categories comple- ted of the WCST were significantly lower （P〈0.05） and accomplishment and pen-up time of the TMT-A and accomplishment time of TMT-B longer （P〈0.05 or 0.01） in TR than in non-TR group, there were no significant differences in other test items （P〉0.05）. Conclusion Impairments of cognitive functions are notably severer in TR than non-TR depression patients.

关 键 词：抑郁症 认知功能 威斯康星卡片分类测验 连线测验 汉密顿抑郁量表 

分 类 号：R749.4[医药卫生—神经病学与精神病学]