慢性酒精中毒性脑病CT与事件相关电位P300对照研究  

Contrast Study in CT and Event-Related Potentials P300 Appearances of Chronic Alcoholic Encephalopathy

作　　者：余红胜[1] 许红莉[2] 鲁杰[2] 

机构地区：[1]湖北孝感市康复医院放射科 [2]湖北孝感市康复医院药物依赖治疗中心

出　　处：《中国医学计算机成像杂志》2015年第5期475-481,共7页Chinese Computed Medical Imaging

摘　　要：目的:分析慢性酒精中毒性脑病(CAE)的CT影像表现及P300潜伏期、波幅变化特点,探讨CT及事件相关电位P300对该病的临床诊断价值。方法:收集37例诊断为CAE病例的临床资料,所有病例均于入院初期行CT和P300检查,结合临床对两种检查结果进行对比分析。结果:CT影像表现异常24例(24/37,64.9%),主要表现为脑萎缩、脑白质变性、脑梗死;其中单一影像表现16例,多病变并存8例;全部37例(37/37,100%)病例P300潜伏期均有显著延长(P<0.001),其中32例伴有波幅显著降低(P<0.001)。结论:CAE患者多伴有脑器质性损害和认知功能障碍,CT与P300检查能分别反映CAE脑中枢器质性和认知功能损害及程度,可为临床CAE的诊疗及预后评估提供理论依据。Purpose： To analyze the CT imaging appearance and P300 latency and amplitude characteristics of chronic alcoholic encephalopathy（CAE）, to explore the clinical diagnosis value of CT scan and event-related potential P300 in the disease. Methods： Thirty-seven clinical materials of patients with CAE were collected, all those 37 patients were examined by CT and P300 on admission, the results of CT were compared with the results of P300 in combine with clinical materials. Results： Twenty-four（24/37, 64.9%） cases were abnormal in CT imaging appearances, which were mainly brain atrophy, cerebral white matter degeneration and cerebral infarction, 16 cases have single imaging findings, 8 cases have multiple imaging findings; the latency of P300 of all 37 cases（37/37,100%） were prolonged（P〈0.001）, 32 of them accompanied with significant reduction in amplitude（P〈0.001）. Conclusion： CAE patients tend to have organic brain disease or cognitive impairment, CT and P300 reflect the damage degree of organic brain disease and cognitive impairment respectively, which can provide evidence for treatment and evaluation of the prognosis.

关 键 词：酒依赖 酒精中毒 脑病 体层摄影术 X线计算机 事件相关电位P300 潜伏期 波幅 

分 类 号：R747.9[医药卫生—神经病学与精神病学] R816.1[医药卫生—临床医学]