Overdose the addiction—A new strategy to ablate cancer cells  

作　　者：LI Lei 

机构地区：[1]Department of Experimental Radiation Oncology, Department of Genetics, The University of Texas M.D.Anderson Cancer Center

出　　处：《Science China(Life Sciences)》2015年第11期1169-1170,共2页中国科学（生命科学英文版）

摘　　要：In the field of antitumor drug development, it is common to see paired images of cultured cancer cells： one mock- treated, and the other subjected to a small molecular drug that leads to cell death or growth suppression （Figure 1）. One＇s common perception is that an inhibitor is at work to inactivate a critical factor or pathway essential for cancer cell survival. In the August issue of Cancer Cell [1], how- ever, a team of researchers from Baylor College of Medi- cine led by Dr. Bert O＇Malley described a completely op- posite path for the annihilation of tumors. Instead of using drugs to inhibit the oncogene targets, they used an activator molecule to overstimulate them. The apparent effectiveness and selectiveness of cancer cell killing are astounding.In the field of antitumor drug development,it is common to see paired images of cultured cancer cells:one mocktreated,and the other subjected to a small molecular drug that leads to cell death or growth suppression(Figure 1).One’s common perception is that an inhibitor is at work to inactivate a critical factor or pathway essential for

关 键 词：癌细胞 小分子药物 药物开发 肿瘤细胞 抗肿瘤 生长抑制 细胞死亡 细胞生存 

分 类 号：R730.5[医药卫生—肿瘤]